Patent US4140653A successfully refreshed from Google Patents.
US4140653A
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Solid support for liquid chromatography
Assignee: Tosoh Corp
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Filing: 1977-10-06
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Granted: 1979-02-20
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Expires: 1997-10-06
Abstract
Abstract In an apparatus for liquid chromatography the improvement which comprises a chromatographic column packed with a solid packing material comprising porous silica gel particles, having a specific surface area of 5 to 1500 m 2 /g, an average pore diameter of 20 to 2000 A and a crosslinked polymer selected from the group consisting of polystyrene, sulfonated polystyrene, polymethyl methacrylate and polyacrylonitrile coating the surface of the fine holes of the porous silica gel particles in an amount of 5 to 50 wt.% of the polymer to silica gel particles, wherein said crosslinked polymer does not contain any extractable polymer.
Inventors
- 👤 Shinichi Imura
- 👤 Kazuyuki Fukano
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 12:21
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/265; B01J20/267; B01D; B01D53/00; B01D53/02; B01D53/025; B01J20/02; B01J20/10; B01J20/103; B01J20/261; B01J20/264; B01J20/28; B01J20/28002; B01J20/28004; B01J20/28054; B01J20/28057; B01J20/28078; B01J20/28095; B01J20/28097; B01J20/281; B01J20/286; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/327; B01J20/3276; B01J20/328; B01J20/3282; B01J2220/00; B01J2220/50; B01J2220/54; B01J2220/58
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
114 words
A solid packing material for liquid chromatography prepared by the process which comprises impregnating inorganic, porous particles having a specific surface area of 5 to 1500 m 2 /g, an average pore diameter of 20 to 2000 A and a particle diameter of 1 μ to 1 mm with a free radical polymerizable monomer, selected from the group consisting of styrene and acrylonitrile, a crosslinking agent and a free radical polymerization initiator; polymerizing the monomer and crosslinking agent with crosslinkage; and extracting any soluble polymer to form a crosslinked polymer on and in the inorganic particles, the crosslinked polymer being present in an amount from 5 to 50 wt.% based on the inorganic particles.
Claim 2
Dependent Claim
114 words
A solid packing material for liquid chromatography prepared by the process which comprises impregnating inorganic, porous particles having a specific surface area of 5 to 1500 m 2 /g, an average pore diameter of 20 to 2000 A and a particle diameter of 1 μ to 1 mm with a free radical polymerizable monomer, selected from the group consisting of styrene and acrylonitrile, a crosslinking agent and a free radical polymerization initiator; polymerizing the monomer and crosslinking agent with crosslinkage; and extracting any soluble polymer to form a crosslinked polymer on and in the inorganic particles, the crosslinked polymer being present in an amount from 5 to 50 wt.% based on the inorganic particles.
Claim 3
Dependent Claim
17 words
The solid packing material of claim 1 wherein the crosslinking agent is the free radical polymerizable monomer.
Claim 4
Dependent Claim
29 words
The solid packing material of claim 1, wherein the free radical polymerization initiator is added at a ratio of more than 1 wt.% to the free radical polymerizable monomer.
Claim 5
Dependent Claim
41 words
The solid packing material of claim 1, wherein a mixture of the free radical polymerizable monomer, the crosslinking agent and the free radical polymerization initiator is adsorbed on the pores of said silica gel particles in a vacuum to impregnate it.
Claim 6
Dependent Claim
25 words
The solid packing material of claim 1, wherein the noncrosslinked polymer is extracted after the free radical polymerization with a solvent for the noncrosslinked polymer.
Claim 7
Dependent Claim
23 words
The solid packing material of claim 1, wherein said monomer is styrene and the crosslinking agent is a divinyl compound or diallyl compound.
Claim 8
Dependent Claim
98 words
In an apparatus for liquid chromatograhy the improvement which comprises a chromatographic column packed with a solid packing material comprising porous silica gel particles, having a specific surface area of 5 to 1500 m 2 /g, an average pore diameter of 20 to 2000 A and a crosslinked polymer selected from the group consisting of polystyrene, sulfonated polystyrene, and polyacrylonitrile coating the surface of the fine holes of the porous silica gel particles in an amount of 5 to 50 wt.% of the polymer to silica gel particles, wherein said crosslinked polymer does not contain any extractable polymer.
Claim 9
Dependent Claim
98 words
In an apparatus for liquid chromatograhy the improvement which comprises a chromatographic column packed with a solid packing material comprising porous silica gel particles, having a specific surface area of 5 to 1500 m 2 /g, an average pore diameter of 20 to 2000 A and a crosslinked polymer selected from the group consisting of polystyrene, sulfonated polystyrene, and polyacrylonitrile coating the surface of the fine holes of the porous silica gel particles in an amount of 5 to 50 wt.% of the polymer to silica gel particles, wherein said crosslinked polymer does not contain any extractable polymer.
Claim 10
Dependent Claim
87 words
A solid packing material for liquid chromatography which comprises porous silica gel particles, having a specific surface area of 5 to 1500 m 2 /g, an average pore diameter of 20 to 2000 A and a crosslinked polymer selected from the group consisting of polystyrene, sulfonated polystyrene, and polyacrylonitrile coating the surface of the fine holes of the porous silica gel particles in an amount of 5 to 50 wt.% of the polymer to silica gel particles, wherein said crosslinked polymer does not contain any extractable polymer.
Claim 11
Dependent Claim
87 words
A solid packing material for liquid chromatography which comprises porous silica gel particles, having a specific surface area of 5 to 1500 m 2 /g, an average pore diameter of 20 to 2000 A and a crosslinked polymer selected from the group consisting of polystyrene, sulfonated polystyrene, and polyacrylonitrile coating the surface of the fine holes of the porous silica gel particles in an amount of 5 to 50 wt.% of the polymer to silica gel particles, wherein said crosslinked polymer does not contain any extractable polymer.
Claim 12
Dependent Claim
14 words
The solid packing material of claim 8, wherein said crosslinked polymer is crosslinked polystyrene.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |