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US4139617A
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19-Oxygenated-androst-5-enes for the enhancement of libido
Assignee: Richardson Vicks Inc
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Filing: 1977-02-07
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Granted: 1979-02-13
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Expires: 1997-02-07
Abstract
Abstract The present invention concerns derivatives of 19-oxygenated-androst-5-enes which are useful in the enhancement of libido and related psychic attitudes.
Inventors
- 👤 Joyce F. Grunwell
- 👤 Vladimir Petrow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 23:16
CPC Classifications
C; C07; C07J; C07J1/00; C07J1/0003; C07J1/0011; C07J1/0018; C07J1/0022; C07J1/0033; C07J1/0037; C07J1/004; C07J1/0048; C07J17/00; C07J21/00; C07J21/005; C07J21/008; C07J51/00; C07J53/00; C07J53/002; C07J53/004; C07J53/005; C07J71/00; C07J71/0005; C07J71/001
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
206 words
A method of enhancing the libido of mammals in need thereof which comprises the administration to such mammals of a libido enchancing effective amount of a 19-oxygenated-androst-5-ene having the formula ##STR2## wherein R 1 , R 3 , R 4 and R 5 are hydrogen and methyl, R 2 is selected from the group consisting of H 2 , oxo and H(OR 10 ), R 6 is selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, lower alkenyl having from 2 to 6 carbon atoms, lower alkynyl having from 2 to 6 carbon atoms and when taken together with OR 7 is oxo, R 7 , r 9 and R 10 are each selected from the group consisting of hydrogen, acyl having from 1 to 12 carbon atoms, an ether radical selected from the group consisting of lower alkyl having from 1 to 3 carbon atoms, trialkylsilyl in which the alkyl group has from 1 to 5 carbon atoms, triphenylsilyl, 2-tetrahydropyranyl, 4-tetrahydropyranyl, 1-cycloalkenyl having from 5 to 7 carbon atoms, 1-methoxycycloalkyl and 1-ethoxycycloalkyl in which the cycloalkyl group has from 5 to 7 carbon atoms, and R 8 is hydrogen and when taken together with OR 8 is oxo.
Claim 2
Independent Claim
206 words
A method of enhancing the libido of mammals in need thereof which comprises the administration to such mammals of a libido enchancing effective amount of a 19-oxygenated-androst-5-ene having the formula ##STR2## wherein R 1 , R 3 , R 4 and R 5 are hydrogen and methyl, R 2 is selected from the group consisting of H 2 , oxo and H(OR 10 ), R 6 is selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, lower alkenyl having from 2 to 6 carbon atoms, lower alkynyl having from 2 to 6 carbon atoms and when taken together with OR 7 is oxo, R 7 , r 9 and R 10 are each selected from the group consisting of hydrogen, acyl having from 1 to 12 carbon atoms, an ether radical selected from the group consisting of lower alkyl having from 1 to 3 carbon atoms, trialkylsilyl in which the alkyl group has from 1 to 5 carbon atoms, triphenylsilyl, 2-tetrahydropyranyl, 4-tetrahydropyranyl, 1-cycloalkenyl having from 5 to 7 carbon atoms, 1-methoxycycloalkyl and 1-ethoxycycloalkyl in which the cycloalkyl group has from 5 to 7 carbon atoms, and R 8 is hydrogen and when taken together with OR 8 is oxo.
Claim 3
Dependent Claim
12 words
A method according to claim 1 in which the mammals are primates.
Claim 4
Dependent Claim
33 words
A method of counteracting depression associated with a diminished libido for primates in need thereof which comprises the administration to such primates of an anti-depression effective amount of a 19-oxygenated-androst-5-ene of claim 1.
Claim 5
Dependent Claim
24 words
A method according to claim 1 in which the 19-oxygenated-androst-5-ene is administered in a total daily dose of from 0.1 milligram to 3 grams.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-12 | 1982-08-14 | 1983-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-12 | 1986-08-14 | 1987-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-12 | 1990-08-14 | 1991-02-13 | $7700.00 | Window Closed / Lapsed |