Patent US4138382A successfully refreshed from Google Patents.
US4138382A
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Hydrophilic, water-swellable, crosslinked, copolymer gel and prosthesis employing same
Assignee: Dow Silicones Corp
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Filing: 1978-05-01
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Granted: 1979-02-06
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Expires: 1998-05-01
Abstract
Abstract A hydrophilic, water-swellable, crosslinked gel is produced by copolymerizing a water soluble vinylic constituent in aqueous solution with olefinic hydrolyzable silanes which contain low molecular weight alkoxy groups. Copolymerization is via the unsaturated groups and crosslinking is by condensation reactions. The copolymer is swellable to a finite extent or to an infinite extent depending upon the water/vinylic monomer volume ratio and upon the vinylic monomer:silane mole ratio. Non-toxic embodiments of the gel are especially useful as prosthesis fillers. Such gels can be used to fill the prosthesis before implantation or the prosthesis can be swollen with an aqueous solution after implantation.
Inventors
- 👤 Keith E. Polmanteer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:03
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/12; A61L; A61L27/00; A61L27/14; A61L27/16; A61L27/50; A61L27/52; C; C08; C08F; C08F230/00; C08F230/04; C08F230/08; C08F230/085; Y; Y10; Y10S; Y10S128/00; Y10S128/21
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
103 words
A water swellable hydrophilic gel comprising a crosslinked copolymer of a water soluble vinylic constituent in aqueous solution and an olefinic hydrolyzable silane having the formula X m R n Si(OR') 4- (n+m) wherein X is an unsaturated group, m is at least 1 and R' and R are organic radicals, n being 0 to 2, wherein the volume ratio of water to vinylic constituent is from about 0.5 to about 10 while the mole ratio of vinylic constituent to hydrolyzable silane is from about 50 to about 600, wherein copolymerization is via the unsaturated groups and wherein crosslinking is by condensation reactions.
Claim 2
Dependent Claim
103 words
A water swellable hydrophilic gel comprising a crosslinked copolymer of a water soluble vinylic constituent in aqueous solution and an olefinic hydrolyzable silane having the formula X m R n Si(OR') 4- (n+m) wherein X is an unsaturated group, m is at least 1 and R' and R are organic radicals, n being 0 to 2, wherein the volume ratio of water to vinylic constituent is from about 0.5 to about 10 while the mole ratio of vinylic constituent to hydrolyzable silane is from about 50 to about 600, wherein copolymerization is via the unsaturated groups and wherein crosslinking is by condensation reactions.
Claim 3
Dependent Claim
38 words
The gel of claim 1 wherein the volume ratio of water to vinylic constituent and the mole ratio of vinylic constituent to hydrolyzable silane are selected to produce a gel which is water swellable to an infinite extent.
Claim 4
Dependent Claim
38 words
The gel of claim 1 wherein the volume ratio of water to vinylic constituent and the mole ratio of vinylic constituent to hydrolyzable silane is selected to produce a gel which is water swellable to a finite extent.
Claim 5
Dependent Claim
32 words
The gel of claim 1 wherein the volume ratio of water to vinylic constituent and the mole ratio of vinylic constituent to hydrolyzable silane is selected to produce a slowly soluble gel.
Claim 6
Dependent Claim
100 words
The gel of claim 1 wherein the vinylic constituent is selected from the group consisting of n-vinylpyrrolidone and copolymers and terpolymers of n-vinylpyrrolidone with minor amounts of comonomers selected from the group consisting of 2,4-pentadiene-1-ol; acrylamide derivatives of the formula ##STR4## wherein R is --H or CH 3 and R' and R" are H, --CH 3 , --C 2 H 5 or --CH 2 CHOHCH 3 ; and hydroxylalkylmethacrylates of the formula ##STR5## wherein R is --CH 2 CH 2 OH; and wherein the olefinic hydrolyzable silane is selected from the group consisting of vinyltrimethoxy-silane, vinyltriethoxysilane, ethylvinyldimethoxysilane, allyltrimethoxysilane and 3-trimethoxysilylpropylmethacrylate.
Claim 7
Dependent Claim
43 words
A surgically implantable mammary prosthesis which comprises: (a) a flexible container made of surgically implantable material having an outer surface shaped to approximate the general form of the human breast; and (b) a filling within the container of the gel of claim 1.
Claim 8
Dependent Claim
20 words
The prosthesis of claim 6 wherein the filling within the container comprises the gel of claims 2, 3 or 4.
Claim 9
Dependent Claim
64 words
The prosthesis of claim 6 wherein the filling within the container comprises an amount of the gel of claim 3 insufficient to support the prosthesis and wherein the container is adapted to supply the gel with an amount of aqueous fluid after the prosthesis has been implanted, the amount of aqueous fluid being sufficient to swell the gel so that the prosthesis is supported.
Claim 10
Dependent Claim
22 words
The prosthesis of claim 8 wherein the container includes a silicone gel valve for supplying a sterile aqueous fluid to the gel.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-05 | 1982-08-07 | 1983-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-05 | 1986-08-07 | 1987-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-05 | 1990-08-07 | 1991-02-06 | $7700.00 | Window Closed / Lapsed |