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US4137401A Expired / Lapsed US ⏱️ 0.0 years remaining

Glycoside-ether-ester compounds

Assignee: Alberta Innovates
•
Filing: 1976-06-21
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Granted: 1979-01-30
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Expires: 1996-06-21
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Abstract

Abstract Carbohydrate antigenic determinants containing a glycosidically linked bridging arm are synthesized and coupled to carrier molecules to form artificial antigens, and to solid supports to form immunoabsorbants. These artificial antigens are used to detect antibodies to the carbohydrate haptens, and to raise antisera specific for the carbohydrate antigenic determinants. The immunoabsorbants are used to purify or remove antibodies to the carbohydrate haptens. Specific examples are given to the synthesis of the Lewis-a, Lewis-b, B, and H(O) blood group antigens; to the preparation of antisera to these artificial antigens, and to the preparation of immunoabsorbants specific for antibodies to these antigens.

Inventors

  • 👤 Raymond U. Lemieux
  • 👤 David R. Bundle
  • 👤 Donald A. Baker

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 03:58
CPC Classifications
C; C07; C07H; C07H3/00; C07H3/06; C07H3/04; Y; Y10; Y10S; Y10S530/00; Y10S530/807

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 46 words
An O-β-glycoside having the general structure ##EQU1## wherein R is an aliphatic hydrocarbon moiety having 3 to 17 carbon atoms and R" is --H, --OH, --NH 2 , --NHNH 2 , --N 3 , or lower alkoxy, and n has a value of 1 to 4.
Claim 2
Dependent Claim 46 words
An O-β-glycoside having the general structure ##EQU1## wherein R is an aliphatic hydrocarbon moiety having 3 to 17 carbon atoms and R" is --H, --OH, --NH 2 , --NHNH 2 , --N 3 , or lower alkoxy, and n has a value of 1 to 4.
Claim 3
Dependent Claim 21 words
The β-glycoside of claim 1 wherein the aldoses are selected from the group consisting of D-glucose, D-galactose, D-mannose, L-fucose, and 2-acetamido-2-deoxy-D-glucose.
Claim 4
Dependent Claim 26 words
The β-glycoside of claim 1 wherein n is two or three and the aldoses present are selected from the group consisting of D-galactose, D-glucosamine and L-fucose.
Claim 5
Dependent Claim 32 words
The β-glycoside of claim 1 wherein R is selected from the group consisting of linear aliphatic hydrocarbons of the general structure (CH 2 ) n where n varies from 5 to 10.
Claim 6
Dependent Claim 28 words
The β-glycoside of claim 1 wherein R" is selected from the group --H, --OH, --NHNH 2 , --N 3 , --OCH 3 and --OCH 2 CH 3 .
Claim 7
Dependent Claim 27 words
The lower oligosaccharide derivatives of claim 1 where n is 2, 3, or 4 and each additional aldose moiety is O-α- or O-β-glycosidically-linked to the preceding aldose.
Claim 8
Dependent Claim 13 words
The oligosaccharide derivative of claim 6 wherein the further attached moieties are O-β-glycosidically-linked.
Claim 9
Dependent Claim 14 words
The lower oligosaccharide derivative of claim 6 wherein the further attached moieties are O-α-glycosidically-linked.

References Cited (Backward Citations)

US2218569A Cited
US3356674A Cited
US3655645A Cited
US3729461A Cited
US3974138A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1982-01-29 1982-07-31 1983-01-30 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1986-01-29 1986-07-31 1987-01-30 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1990-01-29 1990-07-31 1991-01-30 $7700.00 Window Closed / Lapsed

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