Patent US4134986A successfully refreshed from Google Patents.
US4134986A
Expired / Lapsed
US
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Polyoxygenated labdane derivatives
Assignee: Hoechst AG
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Filing: 1977-04-15
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Granted: 1979-01-16
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Expires: 1997-04-15
Abstract
Abstract The invention relates to novel polyoxygenated labdane derivatives and to a process for preparing same. The polyoxygenated labdane derivatives of the invention are characterized by valuable pharmacological properties, for example a hypotensive effect and a positive inotropic activity.
Inventors
- 👤 Balbir S. Bajwa
- 👤 Sujata V. Bhat
- 👤 Horst Dornauer
- 👤 Noel J. DE Souza
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:46
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/78; C07D311/92; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
122 words
A compound of the formula ##STR124## stereoisomers thereof, and acid addition salts of such a compound having a basic group, wherein R 1 , R 2 , R 4 are the same or different and are oxygen or ##STR125## wherein R 6 is hydrogen, alkyl having up to 6 carbon atoms, dialkylaminoalkyl or phenalkyl in which the alkyl has at most 4 carbon atoms, benzoyl, alkanoyl having up to 10 carbon atoms, alkoxycarbonyl having from 2 to 10 carbon atoms, or phenylaminocarbonyl, excepting those two compounds in which, simultaneously, R 4 is oxygen, R 1 is ##STR126## and R 6 is ##STR127## or in which R 4 is oxygen, R 1 is ##STR128## R 2 is ##STR129## and R 6 is hydrogen.
Claim 2
Dependent Claim
122 words
A compound of the formula ##STR124## stereoisomers thereof, and acid addition salts of such a compound having a basic group, wherein R 1 , R 2 , R 4 are the same or different and are oxygen or ##STR125## wherein R 6 is hydrogen, alkyl having up to 6 carbon atoms, dialkylaminoalkyl or phenalkyl in which the alkyl has at most 4 carbon atoms, benzoyl, alkanoyl having up to 10 carbon atoms, alkoxycarbonyl having from 2 to 10 carbon atoms, or phenylaminocarbonyl, excepting those two compounds in which, simultaneously, R 4 is oxygen, R 1 is ##STR126## and R 6 is ##STR127## or in which R 4 is oxygen, R 1 is ##STR128## R 2 is ##STR129## and R 6 is hydrogen.
Claim 3
Dependent Claim
9 words
A compound as in claim 1 which is 8,13-epoxy-1,6,7,9-tetrahydroxy-labd-14-en-11-one.
Claim 4
Dependent Claim
9 words
A compound as in claim 1 which is 8,13-epoxy-7-formyloxy-1,6,9-trihydroxy-labd-14-en-11-one.
Claim 5
Dependent Claim
9 words
A compound as in claim 1 which is 6,7-diacetoxy-1,9-dihydroxy-8,13-epoxy-labd-14-en-11-one.
Claim 6
Dependent Claim
9 words
A compound as in claim 1 which is 8,13-epoxy-6-propionyloxy-1,7,9-trihydroxy-labd-14-en-11-one.
Claim 7
Dependent Claim
30 words
A pharmaceutical composition for the treatment of heart and circulatory disease which comprises an effective amount of a compound as in claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
28 words
A method for the treatment of heart and circulatory disease which comprises administering to a patient suffering therefrom an effective amount of a compound as in claim 1.
References Cited (Backward Citations)
US3631039A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-15 | 1982-07-17 | 1983-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-15 | 1986-07-17 | 1987-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-15 | 1990-07-17 | 1991-01-16 | $7700.00 | Window Closed / Lapsed |