US4134969A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treatment of calcium disorders using aminoalkane-diphosphonic acids
Assignee: Henkel AG and Co KGaA
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Filing: 1976-03-12
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Granted: 1979-01-16
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Expires: 1996-03-12
Abstract
Abstract A method for the treatment of diseases relating to the abnormal deposition or dissolution of difficultly soluble calcium salts in the body or mouths of warm-blooded animals which consists of administering orally, parenterally or topically to said warm-blooded animals, a safe but effective amount of at least one pharmacologically acceptable aminoalkane diphosphonic acid derivative or a water-soluble salt thereof.
Inventors
- 👤 Manfred Schmidt-Dunker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 01:36
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61Q; A61Q11/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
127 words
A method for inhibiting the abnormal deposition or dissolution of difficultly soluble calcium salts in the mouths of warm-blooded animals, which consists essentially in applying to the teeth of said animals a pharmacologically-acceptable amino-alkanediphosphonic acid derivative selected from the group consisting of (A) at least one aminoalkane-diphosphonic acid of the formula ##STR9## wherein R 1 and R 2 are each selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms, and (B) a pharmacologically-acceptable water-soluble salt of (A), said derivative being administered in the form of a dentifrice, an adherent paste, an aqueous solution, a losenge or a chewing gum containing an effective but toxicologically harmless amount therefor, in the range of about 0.01% to about 5% by weight, of said derivative.
Claim 2
Independent Claim
127 words
A method for inhibiting the abnormal deposition or dissolution of difficultly soluble calcium salts in the mouths of warm-blooded animals, which consists essentially in applying to the teeth of said animals a pharmacologically-acceptable amino-alkanediphosphonic acid derivative selected from the group consisting of (A) at least one aminoalkane-diphosphonic acid of the formula ##STR9## wherein R 1 and R 2 are each selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms, and (B) a pharmacologically-acceptable water-soluble salt of (A), said derivative being administered in the form of a dentifrice, an adherent paste, an aqueous solution, a losenge or a chewing gum containing an effective but toxicologically harmless amount therefor, in the range of about 0.01% to about 5% by weight, of said derivative.
Claim 3
Dependent Claim
31 words
A method according to claim 1 wherein said derivative is applied to the teeth of said animals as an aqueous composition having a pH in the range of 5 to 9.
Claim 4
Dependent Claim
48 words
A method for inhibiting the formation of tartar on the teeth of a warm-blooded animal, which comprises contacting said teeth with an aqueous solution having a pH of 5 to 9 and containing 0.5% to 5% by weight of an aminoalkane diphosphonic acid derivative according to claim 1.
Claim 5
Dependent Claim
53 words
A method for inhibiting the formation of tartar on the teeth of a warm-blooded animal, which comprises contacting said teeth with a dentifrice in aqueous medium having a pH in the range of 5 to 9 and containing 0.5% to 5% by weight of an aminoalkane diphosphonic acid derivatives according to claim 1.
References Cited (Backward Citations)
US3442604A
Cited
US4054598A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-15 | 1982-07-17 | 1983-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-15 | 1986-07-17 | 1987-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-15 | 1990-07-17 | 1991-01-16 | $7700.00 | Window Closed / Lapsed |