4"-Deoxy-4"-carbamate and dithiocarbamate derivatives of oleandomycin and its esters

Claim 1

A compound having the formula: ##STR10## and the pharmaceutically acceptable salts thereof wherein each of R 1 and R 2 is selected from the group consisting of hydrogen and alkanoyl having from two to three carbon atoms; X is selected from the group consisting of O and S; R 3 is selected from the group consisting of (i) a first subgroup consisting of: --(C.sub.n H.sub.2n)--Z.sub.1 wherein Z 1 is selected from the group consisting of hydrogen, chloro, bromo, carboalkoxy having from one to four carbon atoms in the alkoxy group, hydroxy, alkoxy having from one to four carbon atoms and dimethylamino; and n is an integer from 1 to 4; with the provisos that each Z 1 is hydroxy, chloro, bromo or dimethylamino, n is an integer from 2 to 4; and when X is O, Z 1 is other than hydroxy or dimethylamino; (ii) a second subgroup consisting of: ##STR11## wherein Z 1 is as defined above. (iii) a third subgroup consisting of: ##STR12## wherein Z 2 is selected from the group consisting of hydrogen, chloro, bromo, carboalkoxy having from one to four carbon atoms in the alkoxy group, alkoxy having from one to four carbon atoms and alkyl having from one to four carbon atoms; and, when X is S, (iv) a fourth subgroup consisting of: --CH.sub.2 --pyridyl.