Patent US4133767A successfully refreshed from Google Patents.
US4133767A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chromatographic apparatus and method
Assignee: Thermo Instrument Systems Inc
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Filing: 1977-06-14
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Granted: 1979-01-09
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Expires: 1997-06-14
Abstract
Abstract Apparatus and method for liquid chromatography applicable to systems employing more than one solvent for the carrier. The forming of bubbles in the pumping means employed is prevented by special pretreatment of at least one solvent of the carrier, the pretreatment involving sparging of the solvent with inert gas.
Inventors
- 👤 Stephen R. Bakalyar
- 👤 Ronald E. Honganen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:46
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/26; G01N30/28; B; B01; B01D; B01D15/00; B01D15/08; B01D15/10; B01D15/16; B01D15/166
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
78 words
In multi-solvent chromatography systems having pumping means for delivering a liquid carrier to a column, the improvement comprising sparging at least one of the solvents before it is supplied to the pumping means with a gas that is inert to the solvent and which has low solubility in the solvent, the sparging being continued for a period of time sufficient to substantially eliminate gases of air from the same and to saturate the solvent with the sparging gas.
Claim 2
Dependent Claim
78 words
In multi-solvent chromatography systems having pumping means for delivering a liquid carrier to a column, the improvement comprising sparging at least one of the solvents before it is supplied to the pumping means with a gas that is inert to the solvent and which has low solubility in the solvent, the sparging being continued for a period of time sufficient to substantially eliminate gases of air from the same and to saturate the solvent with the sparging gas.
Claim 3
Dependent Claim
13 words
A method as in claim 1 in which the sparging gas is helium.
Claim 4
Dependent Claim
43 words
A method as in claim 1 in which the one solvent is sparged while in a vessel having a generally enclosed space overlying the surface of the solvent, the sparging serving to provide an atmosphere of only the sparging gas in said space.
Claim 5
Dependent Claim
24 words
A method as in claim 1 in which at least two solvents are sparged and the sparged solvents used to form the liquid carrier.
Claim 6
Dependent Claim
39 words
A method as in claim 1 in which at least two solvents differing in polarity are supplied to the system and mixed therein to form a carrier, and in which only the less polar of said solvents is sparged.
Claim 7
Dependent Claim
15 words
A method as in claim 5 in which both of said solvents are separately sparged.
Claim 8
Dependent Claim
71 words
A method as in claim 1 in which two solvents are supplied to the system and mixed therein to form a carrier, one of the solvents being of lower polarity than the other, sparging the one solvent with helium, sparging the other solvent with an inert gas which has low solubility in the solvent, and then mixing the sparged solvents and supplying said mixture as a carrier to the pumping means.
Claim 9
Dependent Claim
106 words
In multi-solvent chromatography systems having pumping means for delivering a liquid carrier to a column, the liquid carrier being a mixture of at least two solvents, at least one of which has an objectionable amount of absorbed air gases, the improvement comprising sparging said one solvent before it is mixed with the other solvent, the sparging being carried out by use of a gas that is inert to the solvent and which has low solubility in the solvent, the sparging being continued for a period of time sufficient to substantially eliminate gases of air from the same and to saturate the solvent with the sparging gas.
Claim 10
Dependent Claim
106 words
In multi-solvent chromatography systems having pumping means for delivering a liquid carrier to a column, the liquid carrier being a mixture of at least two solvents, at least one of which has an objectionable amount of absorbed air gases, the improvement comprising sparging said one solvent before it is mixed with the other solvent, the sparging being carried out by use of a gas that is inert to the solvent and which has low solubility in the solvent, the sparging being continued for a period of time sufficient to substantially eliminate gases of air from the same and to saturate the solvent with the sparging gas.
Claim 11
Dependent Claim
35 words
A method as in claim 8 in which the rate with which the sparging gas is supplied is reduced and then continued at a lower rate until said one solvent is supplied to the system.
References Cited (Backward Citations)
US2511833A
Cited
US3926559A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-08 | 1982-07-10 | 1983-01-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-08 | 1986-07-10 | 1987-01-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-08 | 1990-07-10 | 1991-01-09 | $7700.00 | Window Closed / Lapsed |