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US4131682A
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Heteroaryl ketone derivatives
Assignee: Lilly Industries Ltd
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Filing: 1977-10-11
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Granted: 1978-12-26
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Expires: 1997-10-11
Abstract
Abstract Novel heteroaryl ketone derivatives, specifically a class of phenyl heteroaryl methanone derivatives, having anti-allergy activity, pharmaceutical formulations containing diphenylmethane derivatives and methods of treatment utilizing such derivatives.
Inventors
- 👤 Delme Evans
- 👤 John C. Saunders
- 👤 William R. N. Williamson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 01:17
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/32; C07D207/33; C07D207/333; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/22; C07D333/26; C07D333/28
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
57 words
A heteroaryl ketone derivative of formula ##STR5## wherein R 1 is C 1-4 alkyl and Het is a heteroaryl group selected from thienyl and thienyl substituted by from one to three groups selected from halogen and C 1-4 alkyl, or a pharmaceutically acceptable salt thereof, provided that when Het is 2-thienyl, R 1 is C 2-4 alkyl.
Claim 2
Dependent Claim
57 words
A heteroaryl ketone derivative of formula ##STR5## wherein R 1 is C 1-4 alkyl and Het is a heteroaryl group selected from thienyl and thienyl substituted by from one to three groups selected from halogen and C 1-4 alkyl, or a pharmaceutically acceptable salt thereof, provided that when Het is 2-thienyl, R 1 is C 2-4 alkyl.
Claim 3
Dependent Claim
12 words
The compound of claim 1 wherein R 1 is C 2-4 alkyl.
Claim 4
Dependent Claim
10 words
The compound of claim 2 wherein R 1 is ethyl.
Claim 5
Dependent Claim
14 words
The compound of claim 2 wherein Het is selected from thienyl, halothienyl, and methylthienyl.
Claim 6
Dependent Claim
9 words
The compound of claim 3 wherein Het is 2-thienyl.
Claim 7
Dependent Claim
66 words
A pharmaceutical formulation consisting essentially of a therapeutically effectaive amount of an active ingredient being a compound of formula (I) ##STR6## where R 1 is C 1-4 alkyl and Het is a heteroaryl group selected from thienyl and thienyl substituted by from one to three groups selected from halogen and C 1-4 alkyl, or a pharmaceutically acceptable salt thereof; associated with a pharmaceutically acceptable carrier therefor.
Claim 8
Dependent Claim
66 words
A pharmaceutical formulation consisting essentially of a therapeutically effectaive amount of an active ingredient being a compound of formula (I) ##STR6## where R 1 is C 1-4 alkyl and Het is a heteroaryl group selected from thienyl and thienyl substituted by from one to three groups selected from halogen and C 1-4 alkyl, or a pharmaceutically acceptable salt thereof; associated with a pharmaceutically acceptable carrier therefor.
Claim 9
Independent Claim
67 words
A method of treating immediate hypersensitivity diseases in animals, including humans, which comprises administering to an afflicted animal a chemotherapeutically effective amount of a compound of formula (I) ##STR7## wherein R 1 is C 1-4 alkyl and Het is a heteroaryl group selected from thienyl and thienyl substituted by from one to three groups selected from halogen and C 1-4 alkyl, or a pharmaceutically acceptable salt thereof.
Claim 10
Independent Claim
67 words
A method of treating immediate hypersensitivity diseases in animals, including humans, which comprises administering to an afflicted animal a chemotherapeutically effective amount of a compound of formula (I) ##STR7## wherein R 1 is C 1-4 alkyl and Het is a heteroaryl group selected from thienyl and thienyl substituted by from one to three groups selected from halogen and C 1-4 alkyl, or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US4000160A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-25 | 1982-06-26 | 1982-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-25 | 1986-06-26 | 1986-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-25 | 1990-06-26 | 1990-12-26 | $7700.00 | Window Closed / Lapsed |