US4130646A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
Assignee: ER Squibb and Sons LLC
•
Filing: 1976-04-22
•
Granted: 1978-12-19
•
Expires: 1996-04-22
Abstract
Abstract Compounds having the structure <IMAGE> <IMAGE> <IMAGE> and pharmaceutically acceptible salts thereof, wherein R1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthio, alkyl, trifluoromethyl or methylenedioxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkylthio, or trifluoromethyl; R3 is formyl or alkanoyl; m is 1 or 2; and n is 0, 1 or 2, have useful sedative and muscle relaxant activity, and can be used as tranquilizers.
Inventors
- 👤 B. Richard Vogt
- 👤 David A. Cullison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:39
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/02; C07D295/027; C07D295/03; A; A61; A61P; A61P21/00; A61P21/02; A61P25/00; A61P25/20; C07C; C07C17/00; C07C17/26; C07C17/32; C07D295/04; C07D295/06; C07D295/073; C07D295/08; C07D295/096; C07D295/10; C07D295/112; C07D295/116; C07C2602/00; C07C2602/02; C07C2602/04; C07C2602/10
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
86 words
A compound having the formula ##STR12## or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthio, alkyl or trifluoromethyl, and m is 1 or 2 or R 1 is a single methylenedioxy group; R 3 is formyl or alkanoyl; wherein the terms "alkyl", "alkoxy" and "alkylthio" refer to groups having 1 to 10 carbon atoms; the term "alkanoyl" refers to groups having 2 to 10 carbon atoms; and the term "alkanoyloxy" refers to groups having 2 to 11 carbon atoms.
Claim 2
Dependent Claim
86 words
A compound having the formula ##STR12## or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthio, alkyl or trifluoromethyl, and m is 1 or 2 or R 1 is a single methylenedioxy group; R 3 is formyl or alkanoyl; wherein the terms "alkyl", "alkoxy" and "alkylthio" refer to groups having 1 to 10 carbon atoms; the term "alkanoyl" refers to groups having 2 to 10 carbon atoms; and the term "alkanoyloxy" refers to groups having 2 to 11 carbon atoms.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is hydrogen.
Claim 4
Dependent Claim
11 words
A compound in accordance with claim 1 wherein m is 1.
Claim 5
Dependent Claim
18 words
A compound in accordance with claim 1 wherein m is 2 and R 1 is alkyl or alkoxy.
Claim 6
Dependent Claim
27 words
A method of treating psychotic states in mammalian species which comprises administering to a mammalian host a therapeutic amount of a compound as defined in claim 1.
Claim 7
Dependent Claim
29 words
A composition useful for treating psychotic states in mammalian species which comprises a therapeutic amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefore.
Claim 8
Dependent Claim
86 words
A compound having the formula ##STR13## or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthio, alkyl or trifluoromethyl, and m is 1 or 2 or R 1 is a single methylenedioxy group; R 3 is formyl or alkanoyl; wherein the terms "alkyl", "alkoxy" and "alkylthio" refer to groups having 1 to 10 carbon atoms; the term "alkanoyl" refers to groups having 2 to 10 carbon atoms; and the term "alkanoyloxy" refers to groups having 2 to 11 carbon atoms.
Claim 9
Dependent Claim
86 words
A compound having the formula ##STR13## or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthio, alkyl or trifluoromethyl, and m is 1 or 2 or R 1 is a single methylenedioxy group; R 3 is formyl or alkanoyl; wherein the terms "alkyl", "alkoxy" and "alkylthio" refer to groups having 1 to 10 carbon atoms; the term "alkanoyl" refers to groups having 2 to 10 carbon atoms; and the term "alkanoyloxy" refers to groups having 2 to 11 carbon atoms.
Claim 10
Dependent Claim
12 words
A compound in accordance with claim 7 wherein R 1 is hydrogen.
Claim 11
Dependent Claim
11 words
A compound in accordance with claim 7 wherein m is 1.
Claim 12
Dependent Claim
18 words
A compound in accordance with claim 7 wherein m is 2 and R 1 is alkyl or alkoxy.
Claim 13
Dependent Claim
27 words
A method of treating psychotic states in mammalian species which comprises administering to a mammalian host a therapeutic amount of a compound as defined in claim 7.
Claim 14
Dependent Claim
29 words
A composition useful for treating psychotic states in mammalian species which comprises a therapeutic amount of a compound as defined in claim 7 and a pharmaceutically acceptable carrier therefore.
Claim 15
Dependent Claim
11 words
The compound in accordance with claim 7, 1,2,3,4-tetrahydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-1-naphthalenol, 1-acetate, hydrochloride (1:2).
References Cited (Backward Citations)
US3146235A
Cited
US3729474A
Cited
US3547923A
Cited
US3845058A
Cited
FR2100935B1
Cited
US3886168A
Cited
US3919230A
Cited
US4022791A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-18 | 1982-06-19 | 1982-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-18 | 1986-06-19 | 1986-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-18 | 1990-06-19 | 1990-12-19 | $7700.00 | Window Closed / Lapsed |