US4022791A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Aminomethyl-3,4-dihydronaphthalenes
Assignee: Pfizer Inc
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Filing: 1975-06-03
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Granted: 1977-05-10
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Expires: 1995-06-03
Abstract
Abstract Compounds of the formula <IMAGE> and pharmaceutically acceptable salts thereof, wherein X and Y are independently H, F, Cl, Br, alkyl having up to four carbons, or alkoxy having up to four carbons, but X and Y are not both H, and Z is a secondary or tertiary amino group, are useful as analgesics and tranquillizing agents for mammals.
Inventors
- 👤 Willard M. Welch, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:23
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/096; C07C; C07C45/00; C07C45/45; C07C45/46; C07C45/61; C07C45/67; C07C45/673; C07C45/68; C07C45/70; C07C45/71; C07C49/00; C07C49/587; C07C49/703; C07C49/747; C07C49/753; C07C49/755; C07C59/00; C07C59/40; C07C59/76; C07C59/90; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/12; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/10; C07D211/14; C07D211/18; C07D211/30; C07D211/32; C07D211/36; C07D211/40; C07D211/42; C07D211/44; C07D211/46; C07D211/52; C07D211/56; C07D211/58; C07D211/60; C07D211/62; C07D211/66; C07D211/68; C07D211/70; C07D277/00; C07D277/02; C07D277/04; C07D295/10; C07D295/112; C07D295/116; C07D295/12; C07D295/125; C07D295/13; C07D295/16; C07D295/20; C07D295/205; C07D295/22; C07D295/26
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
158 words
A compound having the formula ##STR113## wherein the nitrogen containing ring is selected from the group consisting of morpholino, thiazolidino, pyrrolidino, piperidino, piperazino and 3,4-[dihydropiperidino] dehydropiperidino; R 3 , when taken separately, is a member selected from the group consisting of hydrogen, hydrocarbyl having up to six carbon atoms and free of triple bonds, pyrrolidino, piperidino, phenyl and phenyl substituted by Cl, Br or CF 3 ; R 4 , when taken separately, is a member selected from the group consisting of hydrogen, hydroxyl, alkoxy having up to four carbon atoms, alkanoyloxy having up to six carbon atoms, acetoacetoxy, alkylcarbonyl having up to four carbon atoms, carboxamido, N-alkylcarboxamido having up to seven carbon atoms and the moiety ##STR114## with the proviso that when R 4 is said moiety, said nitrogen containing ring is piperidino or 3,4-dehydropiperidino and R 3 and R 4 , when taken together, are ##STR115## with the proviso that said nitrogen containing ring is piperidino.
Claim 2
Dependent Claim
158 words
A compound having the formula ##STR113## wherein the nitrogen containing ring is selected from the group consisting of morpholino, thiazolidino, pyrrolidino, piperidino, piperazino and 3,4-[dihydropiperidino] dehydropiperidino; R 3 , when taken separately, is a member selected from the group consisting of hydrogen, hydrocarbyl having up to six carbon atoms and free of triple bonds, pyrrolidino, piperidino, phenyl and phenyl substituted by Cl, Br or CF 3 ; R 4 , when taken separately, is a member selected from the group consisting of hydrogen, hydroxyl, alkoxy having up to four carbon atoms, alkanoyloxy having up to six carbon atoms, acetoacetoxy, alkylcarbonyl having up to four carbon atoms, carboxamido, N-alkylcarboxamido having up to seven carbon atoms and the moiety ##STR114## with the proviso that when R 4 is said moiety, said nitrogen containing ring is piperidino or 3,4-dehydropiperidino and R 3 and R 4 , when taken together, are ##STR115## with the proviso that said nitrogen containing ring is piperidino.
Claim 3
Dependent Claim
23 words
A compound of claim 1 wherein the ring containing the nitrogen atom is piperidino, R 3 is 4-p-chlorophenyl and R 4 is 4-hydroxy.
Claim 4
Dependent Claim
23 words
A compound of claim 1 wherein the ring containing the nitrogen atom is piperidino, R 3 is 4-phenyl and R 4 is 4-ethoxy.
Claim 5
Dependent Claim
24 words
A compound of claim 1 wherein the ring containing the nitrogen atom is piperidino and R 3 and R 4 taken together are ##STR116##
Claim 6
Dependent Claim
23 words
A compound of claim 1 wherein the ring containing the nitrogen atom is piperidino, R 3 is 4-phenyl and R 4 is 4-acetoxy.
Claim 7
Dependent Claim
23 words
A compound of claim 1 wherein the ring containing the nitrogen atom is pyrrolidino, R 3 is hydrogen and R 4 is hydrogen.
Claim 8
Dependent Claim
27 words
A compound having the formula ##STR117## in which Z is a member of a group consisting of pyrrolidino, 3-hydroxy-3-phenylpyrrolidino, 4-carboxamidopiperidino, 4-acetoxy-4-phenylpiperidino, 4-ethoxy-4-phenylpiperidino, 4-hydroxy-4-(4-chlorophenyl)-piperidino, 4-methylpiperazino, 4-(2-hydroxyethyl)-piperazino and ##STR118##
Claim 9
Dependent Claim
27 words
A compound having the formula ##STR117## in which Z is a member of a group consisting of pyrrolidino, 3-hydroxy-3-phenylpyrrolidino, 4-carboxamidopiperidino, 4-acetoxy-4-phenylpiperidino, 4-ethoxy-4-phenylpiperidino, 4-hydroxy-4-(4-chlorophenyl)-piperidino, 4-methylpiperazino, 4-(2-hydroxyethyl)-piperazino and ##STR118##
Claim 10
Dependent Claim
1 words
1-(2-[8-chloro-5-methoxy-3,4-dihydronaphthyl]methyl)pyrrolidine.
Claim 11
Dependent Claim
1 words
1-(2-[8-chloro-5-methoxy-3,4-dihydronaphthyl]methyl)pyrrolidine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |