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US4129565A Expired / Lapsed US ⏱️ 0.0 years remaining

Isocarbostyril derivatives

Assignee: Nisshin Seifun Group Inc
•
Filing: 1976-12-16
•
Granted: 1978-12-12
•
Expires: 1996-12-16
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Abstract

Abstract Isocarbostyrils of the formula ##STR1## wherein R 1 represents a lower alkyl group having 1 to 4 carbon atoms, and R 3 and R 4 , same or different, individually means hydrogen or an alkyl, aralkyl or cycloalkyl group provided at least either one of R 3 and R 4 should not be hydrogen, or R 3 and R 4 together with the adjacent nitrogen atom may form a heterocyclic ring, having anti-arrhythmic activity and low toxicity are prepared by reacting a 4-substituted isocarbostyril derivative of the formula ##STR2## wherein R 1 is the same as defined above and R 2 represents ##STR3## or its functional equivalent, e.g. --Ch 2 --CH(OH)CH 2 X in which X represents a halogen atom, with an alkyl amine of the general formula ##STR4## wherein R 3 and R 4 are same as defined above..

Inventors

  • 👤 Hideo Fukushima
  • 👤 Yoshikuni Suzuki

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-26 23:25
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/22; C07D217/24

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 76 words
A 4-(3-substituted amino-2-hydroxy) propoxy-2-alkyl isocarbostyril compound of the formula ##STR25## wherein R 1 represents C 1 to C 4 alkyl, and R 3 and R 4 individually means hydrogen, C 1 to C 6 alkyl, benzyl or cyclohexyl provided that both R 3 and R 4 are not hydrogen, or alternatively R 3 and R 4 , together with their adjacent nitrogen atom, is piperidino, piperazino or methylpiperazino, the acid addition salt or quaternary salt thereof.
Claim 2
Dependent Claim 76 words
A 4-(3-substituted amino-2-hydroxy) propoxy-2-alkyl isocarbostyril compound of the formula ##STR25## wherein R 1 represents C 1 to C 4 alkyl, and R 3 and R 4 individually means hydrogen, C 1 to C 6 alkyl, benzyl or cyclohexyl provided that both R 3 and R 4 are not hydrogen, or alternatively R 3 and R 4 , together with their adjacent nitrogen atom, is piperidino, piperazino or methylpiperazino, the acid addition salt or quaternary salt thereof.
Claim 3
Dependent Claim 27 words
A 4-(3-substituted amino-2-hydroxy)propoxy-2-alkylisocarbostyril compound as claimed in claim 1, wherein said compound is in the form of an acid addition salt with an inorganic or organic acid.
Claim 4
Dependent Claim 23 words
A 4-(3-substituted amino-2-hydroxy)propoxy-2-alkylisocarbostyril compound as claimed in claim 1, said compound is in the form of a quaternary salt with an alkyl iodide.
Claim 5
Dependent Claim 2 words
4-(3-isopropylamino-2-hydroxy)propoxy-2-methylisocarbostyril hydrochloride.
Claim 6
Dependent Claim 2 words
4-(3-isopropylamino-2-hydroxy)propoxy-2-methylisocarbostyril hydrochloride.
Claim 7
Dependent Claim 2 words
4-(3-tert.-butylamino-2-hydroxy)propoxy-2-methylisocarbostyril hydrochloride.
Claim 8
Dependent Claim 2 words
4-(3-tert.-butylamino-2-hydroxy)propoxy-2-methylisocarbostyril hydrochloride.
Claim 9
Dependent Claim 3 words
4-(3-sec.-butylamino-2-hydroxy)propoxy-2-methyl isocarbostyril hydrochloride.
Claim 10
Dependent Claim 3 words
4-(3-sec.-butylamino-2-hydroxy)propoxy-2-methyl isocarbostyril hydrochloride.

References Cited (Backward Citations)

US3910924A Cited
DE2447756A1 Cited
US4013663A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1981-12-11 1982-06-12 1982-12-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1985-12-11 1986-06-12 1986-12-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1989-12-11 1990-06-12 1990-12-12 $7700.00 Window Closed / Lapsed

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