Patent US4128399A successfully refreshed from Google Patents.
US4128399A
Expired / Lapsed
US
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Device and method for detecting phenothiazine-type drugs in urine
Assignee: Individual
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Filing: 1976-03-15
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Granted: 1978-12-05
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Expires: 1996-03-15
Abstract
Abstract A device and method is provided for the qualitative and semi-quantitative determination of the presence of phenothiazine-type drugs in urine. The article comprises an ion exchange resin which denotes cations in a reaction between a color forming reagent and the phenothiazine-type drug to produce a permanent color change. The intensity of the color change is proportional to the dose concentration.
Inventors
- 👤 Lance A. Liotta
- 👤 Robert S. Weiss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:00
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/94; B; B01; B01J; B01J39/00; B01J39/04; B01J39/05; B01J39/08; B01J39/16; B01J39/17; B01J39/26; B01J2220/00; B01J2220/50; B01J2220/54; Y; Y10; Y10T; Y10T436/00; Y10T436/14; Y10T436/141111
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
108 words
A device for determining the presence of a phenothiazine-type drug in urine comprising a substrate supporting a mass of cation exchange resin impregnated with a color forming reagent, said ion-exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion-exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said color forming reagent being present in an amount sufficient to cause a color change to occur in said device when brought into contact with a urine specimen containing a phenothiazine-type drug.
Claim 2
Independent Claim
108 words
A device for determining the presence of a phenothiazine-type drug in urine comprising a substrate supporting a mass of cation exchange resin impregnated with a color forming reagent, said ion-exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion-exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said color forming reagent being present in an amount sufficient to cause a color change to occur in said device when brought into contact with a urine specimen containing a phenothiazine-type drug.
Claim 3
Dependent Claim
13 words
The device of claim 1 wherein said color forming reagent produces ferric ions.
Claim 4
Dependent Claim
13 words
The device of claim 3 wherein said color forming reagent is ferric chloride.
Claim 5
Dependent Claim
15 words
The device of claim 1 wherein said cation exchange resin is in its hydrogen form.
Claim 6
Dependent Claim
15 words
The device of claim 1 wherein said cation exchange resin is present in pellet form.
Claim 7
Dependent Claim
39 words
The device of claim 1 wherein said cation exchange resin is present in an amount such that when contacted with a urine specimen the pH of the specimen in immediate contact with said resin is less than about 1.
Claim 8
Independent Claim
123 words
The method of detecting the presence of a phenothiazine-type drug in urine comprising, contacting a mass of cation exchange resin impregnated with a color forming reagent, said ion exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said reagent being present in an amount sufficient to cause a color change to occur in said device when brought into contact with a urine specimen containing a phenothiazine-type drug, with urine specimen; and observing any color change therein to determine the presence of a phenothiazine-type drug.
Claim 9
Independent Claim
123 words
The method of detecting the presence of a phenothiazine-type drug in urine comprising, contacting a mass of cation exchange resin impregnated with a color forming reagent, said ion exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said reagent being present in an amount sufficient to cause a color change to occur in said device when brought into contact with a urine specimen containing a phenothiazine-type drug, with urine specimen; and observing any color change therein to determine the presence of a phenothiazine-type drug.
Claim 10
Dependent Claim
18 words
The method of claim 7 wherein in said mass of cation exchange resin is positioned on a substrate.
Claim 11
Dependent Claim
13 words
The method of claim 7 wherein said color forming reagent produces ferric ions.
Claim 12
Dependent Claim
13 words
The method of claim 9 wherein said color forming reagent is ferric chloride.
Claim 13
Dependent Claim
15 words
The method of claim 7 wherein said cation exchange resin is in its hydrogen form.
Claim 14
Dependent Claim
15 words
The method of claim 7 wherein said cation exchange resin is present in pellet form.
Claim 15
Dependent Claim
39 words
The method of claim 7 wherein said cation exchange resin is present in an amount such that when contacted with a urine specimen the pH of the specimen in immediate contact with said resin is less than about 1.
Claim 16
Independent Claim
112 words
A device for determining the presence of tricyclic antidepressant drugs of the phenothiazine-type in urine comprising a substrate supporting a mass of cation exchange resin impregnated with a color forming reagent, said ion-exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion-exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said reagent being present in an amount sufficient to cause a color change to occur in said device when brought into contact with a urine specimen containing a tricyclic drug of the phenothiazine-type.
Claim 17
Independent Claim
112 words
A device for determining the presence of tricyclic antidepressant drugs of the phenothiazine-type in urine comprising a substrate supporting a mass of cation exchange resin impregnated with a color forming reagent, said ion-exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion-exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said reagent being present in an amount sufficient to cause a color change to occur in said device when brought into contact with a urine specimen containing a tricyclic drug of the phenothiazine-type.
Claim 18
Dependent Claim
24 words
The device of claim 14 wherein said color forming reagent is selected from the group consisting of potassium dichromate, ceric ammoniumnitrate and mixtures thereof.
Claim 19
Dependent Claim
13 words
The device of claim 15 wherein said color forming reagent is ceric ammoniumnitrate.
Claim 20
Dependent Claim
13 words
The device of claim 15 wherein said color forming reagent is potassium dichromate.
Claim 21
Dependent Claim
15 words
The device of claim 14 wherein said cation exchange resin is in its hydrogen form.
Claim 22
Dependent Claim
15 words
The device of claim 14 wherein said cation exchange resin is present in pellet form.
Claim 23
Dependent Claim
39 words
The device of claim 14 wherein said cation exchange resin is present in an amount such that when contacted with a urine specimen the pH of the specimen in immediate contact with said resin is less than about 1.
Claim 24
Independent Claim
106 words
A method of detecting the presence of a tricyclic antidepressant drug of the phenothiazine type in urine which comprises contacting a mass of cation exchange resin impregnated with a color forming reagent, said ion exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said regent being present in said device when brought into contact with a urine specimen containing a tricyclic antidepressant drug of the phenothiazine type.
Claim 25
Independent Claim
106 words
A method of detecting the presence of a tricyclic antidepressant drug of the phenothiazine type in urine which comprises contacting a mass of cation exchange resin impregnated with a color forming reagent, said ion exchange resin being present in an amount sufficient to liberate adequate hydrogen ions to cause the solution being tested in the area in immediate contact with said ion exchange resin to have a pH sufficient to cause said color forming reagent to react with said phenothiazine-type drug, and said regent being present in said device when brought into contact with a urine specimen containing a tricyclic antidepressant drug of the phenothiazine type.
Claim 26
Dependent Claim
18 words
The method of claim 21 wherein in said mass of cation exchange resin is positioned on a substrate.
Claim 27
Dependent Claim
24 words
The device of claim 21 wherein said color forming reagent is selected from the group consisting of potassium dichromate, ceric ammoniumnitrate and mixtures thereof.
Claim 28
Dependent Claim
13 words
The method of claim 21 wherein said color forming reagent is ceric ammoniumnitrate.
Claim 29
Dependent Claim
13 words
The method of claim 21 wherein said color forming reagent is potassium dichromate.
Claim 30
Dependent Claim
15 words
The method of claim 21 wherein said cation exchange resin is in its hydrogen form.
Claim 31
Dependent Claim
15 words
The method of claim 21 wherein said cation exchange resin is present in pellet form.
Claim 32
Dependent Claim
39 words
The method of claim 21 wherein said cation exchange resin is present in an amount such that when contacted with a urine specimen the pH of the specimen in immediate contact with said resin is less than about 1.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-04 | 1982-06-05 | 1982-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-04 | 1986-06-05 | 1986-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-04 | 1990-06-05 | 1990-12-05 | $7700.00 | Window Closed / Lapsed |