Patent US4126680A successfully refreshed from Google Patents.
US4126680A
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Tetracycline antibiotic compositions
Assignee: Pfizer Inc
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Filing: 1977-04-27
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Granted: 1978-11-21
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Expires: 1997-04-27
Abstract
Abstract Aqueous solutions of oxytetracycline, doxycycline or chlortetracycline in caprolactam or 2-piperidone are disclosed.
Inventors
- 👤 William W. Armstrong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 13:54
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/32; A61K31/00; A61K31/65; A61K47/06; A61K47/22; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
154 words
A liquid composition comprising an aqueous solution of a tetracycline antibiotic in caprolactam or 2-piperidone, said tetracycline being selected from the group consisting of oxytetracycline in a concentration of from about 5 to 30% w/v, doxycycline in a concentration of from about 5 to 20% w/v, chlortetracycline in a concentration of from about 5 to 15% w/v, and the pharmaceutically acceptable acid addition salts thereof, with the proviso that when said tetracycline antibiotic is oxytetracycline or its pharmaceutically-acceptable acid addition salts the caprolactam or 2-piperidone is present in a concentration of from about 30 to 60% w/v, when said tetracycline antibiotic is doxycycline or its pharmaceutically-acceptable acid addition salts the caprolactam or 2-piperidone is present in a concentration of from about 50 to 70% w/v, and when said tetracycline antibiotic is chlortetracycline or its pharmaceutically-acceptable acid addition salts the caprolactam or 2-piperidone is present in a concentration of from about 60 to 70% w/v.
Claim 2
Dependent Claim
154 words
A liquid composition comprising an aqueous solution of a tetracycline antibiotic in caprolactam or 2-piperidone, said tetracycline being selected from the group consisting of oxytetracycline in a concentration of from about 5 to 30% w/v, doxycycline in a concentration of from about 5 to 20% w/v, chlortetracycline in a concentration of from about 5 to 15% w/v, and the pharmaceutically acceptable acid addition salts thereof, with the proviso that when said tetracycline antibiotic is oxytetracycline or its pharmaceutically-acceptable acid addition salts the caprolactam or 2-piperidone is present in a concentration of from about 30 to 60% w/v, when said tetracycline antibiotic is doxycycline or its pharmaceutically-acceptable acid addition salts the caprolactam or 2-piperidone is present in a concentration of from about 50 to 70% w/v, and when said tetracycline antibiotic is chlortetracycline or its pharmaceutically-acceptable acid addition salts the caprolactam or 2-piperidone is present in a concentration of from about 60 to 70% w/v.
Claim 3
Dependent Claim
80 words
A composition as claimed in claim 1 comprising an aqueous solution of from about 5 to 30% w/v of an antibiotic compound selected from the group consisting of oxytetracycline and the pharmaceutically acceptable acid addition salts thereof, from about 0.8 to 1.1 molar proportions based on said antibiotic of a pharmaceutically acceptable magnesium compound soluble in said solution and from about 30 to 60% w/v of caprolactam or 2-piperidone, said composition having a pH of from about 7.5 to 9.5.
Claim 4
Dependent Claim
13 words
A composition as claimed in claim 2 wherein said antibiotic compound is oxytetracycline.
Claim 5
Dependent Claim
19 words
A composition as claimed in claim 2 wherein said magnesium compound is introduced in the form of magnesium oxide.
Claim 6
Dependent Claim
23 words
A composition as claimed in claim 2 wherein said antibiotic compound is present at a level of from about 20 to 30% w/v.
Claim 7
Dependent Claim
17 words
A composition as claimed in claim 2 having a pH value of from about 8.5 to 9.
Claim 8
Dependent Claim
22 words
A composition as claimed in claim 2 wherein polyvinylpyrrolidone is also present in a concentration of from about 1 to 7% w/v.
Claim 9
Dependent Claim
16 words
A composition according to claim 1 comprising an aqueous solution of a tetracycline antibiotic in caprolactam.
Claim 10
Dependent Claim
67 words
An oxytetracycline composition comprising an aqueous solution of from about 20 to 30% w/v of oxytetracycline, from about 0.8 to 1.1 molar proportions of a pharmaceutically acceptable magnesium compound soluble in said solution, from about 40 to 50% w/v of caprolactam or 2-piperidone and from about 1 to 7% w/v of polyvinylpyrrolidone, said composition having a pH value in the range of from about 8.5 to 9.
Claim 11
Dependent Claim
67 words
An oxytetracycline composition comprising an aqueous solution of from about 20 to 30% w/v of oxytetracycline, from about 0.8 to 1.1 molar proportions of a pharmaceutically acceptable magnesium compound soluble in said solution, from about 40 to 50% w/v of caprolactam or 2-piperidone and from about 1 to 7% w/v of polyvinylpyrrolidone, said composition having a pH value in the range of from about 8.5 to 9.
Claim 12
Dependent Claim
21 words
A composition according to claim 9 comprising an aqueous solution of oxytetracycline in from about 40 to 50% w/v of caprolactam.
Claim 13
Dependent Claim
84 words
A composition as claimed in claim 1 comprising an aqueous solution of from about 5 to 20% w/v of an antibiotic compound selected from the group consisting of doxycycline and the pharmaceuticaly acceptable acid addition salts thereof, from about 1.8 to 2.2 molar proportions based on said antibiotic of a pharmaceutically acceptable magnesium compound soluble in said solution, and from about 50 to 70% w/v of caprolactam or 2-piperidone, said composition having a pH value in the range of from about 3.5 to 7.5.
Claim 14
Dependent Claim
12 words
A composition as claimed in claim 11 wherein said antibiotic is doxycycline.
Claim 15
Dependent Claim
19 words
A composition as claimed in claim 11 wherein said magnesium compound is introduced in the form of magnesium oxide.
Claim 16
Dependent Claim
23 words
A composition as claimed in claim 11 wherein said antibiotic compound is present at the level of from about 10 to 20% w/v.
Claim 17
Dependent Claim
22 words
A composition as claimed in claim 11 wherein polyvinylpyrrolidone is also present in a concentration of from about 1 to 7% w/v.
Claim 18
Dependent Claim
70 words
A doxycycline composition comprising an aqueous solution of from about 10 to 20% w/v of doxycycline, from about 1.8 to 2.2 molar proportions based on doxycycline of a pharmaceutically acceptable magnesium compound soluble in said solution, from about 50 to 70% w/v of caprolactam or 2-piperidone and from about 1 to 7% w/v of polyvinylpyrrolidone, said composition having a pH value in the range of from about 3.5 to 7.5.
Claim 19
Dependent Claim
70 words
A doxycycline composition comprising an aqueous solution of from about 10 to 20% w/v of doxycycline, from about 1.8 to 2.2 molar proportions based on doxycycline of a pharmaceutically acceptable magnesium compound soluble in said solution, from about 50 to 70% w/v of caprolactam or 2-piperidone and from about 1 to 7% w/v of polyvinylpyrrolidone, said composition having a pH value in the range of from about 3.5 to 7.5.
Claim 20
Dependent Claim
21 words
A composition according to claim 16 comprising an aqueous solution of doxycycline in from about 50 to 70% w/v of caprolactam.
Claim 21
Dependent Claim
84 words
A composition as claimed in claim 1 comprising an aqueous solution of from about 5 to 15% w/v of an antibiotic compound selected from the group consisting of chlortetracycline and the pharmaceutically acceptable acid addition salts thereof, from about 1.8 to 2.2 molar proportions based on said antibiotic of a pharmaceutically acceptable calcium compound soluble in said solution, and from about 60 to 70% w/v of caprolactam or 2-piperidone, said composition having a pH value in the range of from about 8.5 to 9.5.
Claim 22
Dependent Claim
14 words
A composition as claimed in claim 18 wherein said antibiotic compound is chlortetracycline hydrochloride.
Claim 23
Dependent Claim
19 words
A composition as claimed in claim 18 wherein said calcium compound is introduced in the form of calcium chloride.
Claim 24
Dependent Claim
23 words
A composition as claimed in claim 18 wherein said antibiotic compound is present at a level of from about 10 to 15% w/v.
Claim 25
Dependent Claim
21 words
A composition as claimed in claim 18 wherein polyvinylpyrrolidone is also present in a concentration of from about 1 to w/v.
Claim 26
Dependent Claim
70 words
A chlortetracycline composition comprising an aqueous solution of from about 10 to 15% w/v of chlortetracycline, from about 1.8 to 2.2 molar proportions based on chlortetracycline of a pharmaceutically accpetable calcium compound soluble in said solution, from about 60 to 70% w/v of caprolactam or 2-piperidone, and from about 1 to 7% w/v of polyvinylpyrrolidone, said composition having a pH value in the range of from about 8.5 to 9.
Claim 27
Dependent Claim
70 words
A chlortetracycline composition comprising an aqueous solution of from about 10 to 15% w/v of chlortetracycline, from about 1.8 to 2.2 molar proportions based on chlortetracycline of a pharmaceutically accpetable calcium compound soluble in said solution, from about 60 to 70% w/v of caprolactam or 2-piperidone, and from about 1 to 7% w/v of polyvinylpyrrolidone, said composition having a pH value in the range of from about 8.5 to 9.
Claim 28
Dependent Claim
21 words
A composition according to claim 23 comprising an aqueous solution of chlortetracycline in from about 60 to 70% w/v of caprolactam.
References Cited (Backward Citations)
US4018889A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-20 | 1982-05-22 | 1982-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-20 | 1986-05-22 | 1986-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-20 | 1990-05-22 | 1990-11-21 | $7700.00 | Window Closed / Lapsed |