Abstract Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
In a method of preparing solid pharmaceutical unit dosage forms comprising loading one or more medicaments to a therapeutically inert, edible web, having a composition such that it is amenable to being watersealed, fabricating said loaded web into a solid geometric form of predetermined shape having said medicament substantially internalized, said form being divisible into a plurality of unit dosage forms, unitizing said geometric form into said plurality of unit dosage forms and sealing said unit dosage forms to completely internalize said medicament wherein said fabricating procedure comprises cutting said loaded web transversely to form substantially uniform lengths of web. corrugating each length of web to form same into a loosely wound coil and convolute winding said loose coil to form a substantially solid rod, the improvement in sealing said rods which comprises contacting said coils with a sufficient amount of water as a fine spray to dampen them and subsequently drying said rods.
Claim 2
Dependent Claim
154 words
In a method of preparing solid pharmaceutical unit dosage forms comprising loading one or more medicaments to a therapeutically inert, edible web, having a composition such that it is amenable to being watersealed, fabricating said loaded web into a solid geometric form of predetermined shape having said medicament substantially internalized, said form being divisible into a plurality of unit dosage forms, unitizing said geometric form into said plurality of unit dosage forms and sealing said unit dosage forms to completely internalize said medicament wherein said fabricating procedure comprises cutting said loaded web transversely to form substantially uniform lengths of web. corrugating each length of web to form same into a loosely wound coil and convolute winding said loose coil to form a substantially solid rod, the improvement in sealing said rods which comprises contacting said coils with a sufficient amount of water as a fine spray to dampen them and subsequently drying said rods.