Patent US4125327A successfully refreshed from Google Patents.
US4125327A
Expired / Lapsed
US
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Method and apparatus for simultaneously recording reaction times
Assignee: Gradient Pty Ltd
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Filing: 1976-11-01
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Granted: 1978-11-14
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Expires: 1996-11-01
Abstract
Abstract An apparatus and method of determining the end point of a chemical reaction producing an optical change in a plurality of samples is disclosed. The invention is particularly suitable for the simultaneous determination of the coagulation time for multiple samples of blood and like materials.
Inventors
- 👤 Joel Margolis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:48
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/251; G01N21/253; B; B01; B01F; B01F35/00; B01F35/20; B01F35/21; B01F35/213
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
179 words
Apparatus for simultaneously determining the completion time, of chemical reactions producing an optical change, in a plurality of chemical samples each of which is contained in a transparent container and includes a suspension containing fibrin and an added particulate substance to which fibrin is capable of adhering, said apparatus comprising retention means to locate the plurality of containers with each container interposed in a light path between a corresponding light source and a corresponding light sensor, and agitator insertable within said containers and movable to agitate said samples, a timer connected with said light sensors and operable by the outputs thereof, and means for switching on the timer, the latter means being operated with the commencement of the reaction in the containers, and means for stopping the timer constituted by the provision wherein, said particulate substance is so constituted that fibrin mesh formed by the samples during the chemical reaction traps the particles of said suspension and is swept away during agitation of the samples such that the timer is stopped by an increase of light to the detector.
Claim 2
Dependent Claim
179 words
Apparatus for simultaneously determining the completion time, of chemical reactions producing an optical change, in a plurality of chemical samples each of which is contained in a transparent container and includes a suspension containing fibrin and an added particulate substance to which fibrin is capable of adhering, said apparatus comprising retention means to locate the plurality of containers with each container interposed in a light path between a corresponding light source and a corresponding light sensor, and agitator insertable within said containers and movable to agitate said samples, a timer connected with said light sensors and operable by the outputs thereof, and means for switching on the timer, the latter means being operated with the commencement of the reaction in the containers, and means for stopping the timer constituted by the provision wherein, said particulate substance is so constituted that fibrin mesh formed by the samples during the chemical reaction traps the particles of said suspension and is swept away during agitation of the samples such that the timer is stopped by an increase of light to the detector.
Claim 3
Dependent Claim
64 words
2. The apparatus as claimed in claim 1 wherein each said container has an open top, said retention means retains said containers upright and positioned in a row, and said agitator is transparent and comprises a comb having a base and a plurality of spaced parallel fingers, each of said fingers being insertable into a corresponding one of said containers via its open top.
Claim 4
Dependent Claim
52 words
The apparatus as claimed in claim 2 wherein the base of said comb has a slot therethrough transverse to said fingers and a pin is slidably positioned in said slot, said pin being substantially parallel to and displaced from a shaft, whereby rotation of said shaft produces longtudinal reciprocation of said fingers.
Claim 5
Dependent Claim
27 words
The apparatus as claimed in claim 3 including control means to maintain said samples at a constant temperature while said containers are located in said retention means.
Claim 6
Dependent Claim
74 words
The apparatus as claimed in claim 4 wherein said control means comprises a heated metal block, said retention means comprises an array of container receiving recesses in said block, said light sources are positioned to one side of said block, said light sensors are positioned on the other side of said block, and each said light path comprises a bore extending between said sides of said block and through the corresponding container receiving recess.
Claim 7
Dependent Claim
30 words
The apparatus as claimed in claim 5 including preheating means comprising a metal body in thermal communication with said heated block and including a like number of container receiving recesses.
Claim 8
Independent Claim
119 words
A method of simultaneously determining the completion time, of a chemical reaction producing an optical change, in a plurality of chemical samples comprising a suspension containing fibrin, said method comprising the steps of adding to each sample a particulate substance to which fibrin is capable of adhering, placing each said sample in a transparent container, initiating said reaction and simultaneously switching-on a timing means, agitating said samples within said containers so that a fibrin mesh formed in the samples traps the particles of the suspension and the mesh is swept away during the agitation of the samples to cause the samples to be suddenly and rapidly rendered transparent, and switching-off said timing means when the samples are rendered transparent.
Claim 9
Independent Claim
119 words
A method of simultaneously determining the completion time, of a chemical reaction producing an optical change, in a plurality of chemical samples comprising a suspension containing fibrin, said method comprising the steps of adding to each sample a particulate substance to which fibrin is capable of adhering, placing each said sample in a transparent container, initiating said reaction and simultaneously switching-on a timing means, agitating said samples within said containers so that a fibrin mesh formed in the samples traps the particles of the suspension and the mesh is swept away during the agitation of the samples to cause the samples to be suddenly and rapidly rendered transparent, and switching-off said timing means when the samples are rendered transparent.
Claim 10
Dependent Claim
43 words
The method as claimed in claim 7 wherein each said container is placed in a corresponding light path between a corresponding light source and a corresponding light sensor, and said timing means is switched off in response to the outputs of said sensors.
Claim 11
Dependent Claim
22 words
The method as claimed in claim 8 wherein said samples are maintained at a pre-determined temperature while positioned in said light paths.
Claim 12
Dependent Claim
16 words
The method as claimed in claim 7 wherein said particles are kaolin, cellulose or diatomaceous earth.
Claim 13
Dependent Claim
37 words
The method as claimed in claim 10 wherein said containers have open tops and each said sample is agitated by longitudinal reciprocation of an elongated finger extending through the open top of the container holding said sample.
Claim 14
Dependent Claim
32 words
The apparatus as claimed in claim 3 wherein said pin is removable from said slot to enable separation of said comb from said shaft and removable of the comb from said containers.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-13 | 1982-05-15 | 1982-11-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-13 | 1986-05-15 | 1986-11-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-13 | 1990-05-15 | 1990-11-14 | $7700.00 | Window Closed / Lapsed |