Patent US4124702A successfully refreshed from Google Patents.
US4124702A
Expired / Lapsed
US
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Polynucleotides active as inducers of interferon production in living animal cells
Assignee: Merck and Co Inc
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Filing: 1976-12-14
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Granted: 1978-11-07
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Expires: 1996-12-14
Abstract
Abstract Polynucleotides which are multistranded are active as inducers of interferon production in living animal cells. They may be:
Inventors
- 👤 George P. Lampson
- 👤 Alfred A. Tytell
- 👤 Arthur K. Field
- 👤 Maurice R. Hilleman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:16
CPC Classifications
C; C07; C07H; C07H21/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
84 words
The method of stimulating the production of species-specific interferon in living animal cells which involves subjecting said cells to the species-specific interferon inducing effect of a doublestranded polynucleotide in the substantial absence of an inhibiting factor wherein said doublestranded polynucleotide is a synthetic chemically defined non-toxic, non-antigenic, non-replicating polymer resulting from the complexing of 1:1 molar ratios, with respect to their bases, of polyinosinic acid and polycytidylic acid, which themselves are synthetic, and each lacking the capacity to induce the production of species-specific interferon.
Claim 2
Independent Claim
84 words
The method of stimulating the production of species-specific interferon in living animal cells which involves subjecting said cells to the species-specific interferon inducing effect of a doublestranded polynucleotide in the substantial absence of an inhibiting factor wherein said doublestranded polynucleotide is a synthetic chemically defined non-toxic, non-antigenic, non-replicating polymer resulting from the complexing of 1:1 molar ratios, with respect to their bases, of polyinosinic acid and polycytidylic acid, which themselves are synthetic, and each lacking the capacity to induce the production of species-specific interferon.
Claim 3
Dependent Claim
17 words
The method according to claim 1 in which the cells are contained in a nutrient culture medium.
Claim 4
Dependent Claim
18 words
The method according to claim 1 in which the cells are those of a living animal or human.
References Cited (Backward Citations)
US3629235A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-06 | 1982-05-08 | 1982-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-06 | 1986-05-08 | 1986-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-06 | 1990-05-08 | 1990-11-07 | $7700.00 | Window Closed / Lapsed |