US4123538A
Expired / Lapsed
US
⏱️ 0.0 years remaining
(2-Amino-2-oxoethoxy)acetic acid compounds, compositions and methods
Assignee: Janssen Pharmaceuticals Inc
•
Filing: 1977-08-30
•
Granted: 1978-10-31
•
Expires: 1997-08-30
Abstract
Abstract Novel (2-amino-2-oxoethoxy)acetic acid compounds and antisecretory compositions and methods employing (2-amino-2-oxoethoxy)acetic acid compounds are disclosed. The (2-amino-2-oxoethoxy)acetic acid compounds are also useful as cardiotonic agents and as calcium binding agents; certain of the compounds are also useful for their calcium transport properties. Novel 4-substituted 3,5-morpholinediones intermediates in the preparation of certain of the (2-amino-2-oxoethoxy)acetic acid compounds and further useful as antisecretory agents are also disclosed.
Inventors
- 👤 Michael J. Umen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:07
CPC Classifications
C; C07; C07D; C07D265/00; C07D265/28; C07D265/30; C07D265/32; C07D265/33; A; A61; A61P; A61P1/00; A61P1/04; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/10; C07D211/16; C07D295/00; C07D295/04; C07D295/12; C07D295/125; C07D295/13; C07D413/00; C07D413/02; C07D413/06
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
65 words
A pharmaceutical composition suitable for inhibiting gastric secretion in dosage unit form comprising per dosage unit from about 10 to about 500 milligrams of a (2-amino-2-oxoethoxy)acetic acid compound represented by the formula ##STR28## wherein M is hydrogen, alkali metal, alkaline earth metal, ammonium, alkylammonium or hydroxyalkylammonium; and Z is a radical represented by ##STR29## wherein Ar is phenyl, trifluoromethylphenyl, halo-substituted-phenyl, lower alkyl-substituted-phenyl, or lower alkoxy-substituted-phenyl.
Claim 2
Dependent Claim
65 words
A pharmaceutical composition suitable for inhibiting gastric secretion in dosage unit form comprising per dosage unit from about 10 to about 500 milligrams of a (2-amino-2-oxoethoxy)acetic acid compound represented by the formula ##STR28## wherein M is hydrogen, alkali metal, alkaline earth metal, ammonium, alkylammonium or hydroxyalkylammonium; and Z is a radical represented by ##STR29## wherein Ar is phenyl, trifluoromethylphenyl, halo-substituted-phenyl, lower alkyl-substituted-phenyl, or lower alkoxy-substituted-phenyl.
Claim 3
Independent Claim
73 words
A method for inhibiting gastric secretion which comprises administering to a subject with gastric hyperacidity an effective antisecretory amount of a (2-amino-2-oxoethoxy)acetic acid compound represented by the formula ##STR30## wherein M is hydrogen, alkali metal, alkaline earth metal, ammonium, alkylammonium or hydroxyalkylammonium; and Z is a radical represented by ##STR31## wherein Ar is phenyl, trifluoromethylphenyl, halo-substituted-phenyl, lower alkyl-substituted-phenyl, or lower alkoxy-substituted-phenyl, said (2-amino-2-oxoethoxy)acetic acid compound being supplied in admixture with a pharmaceutical carrier.
Claim 4
Independent Claim
73 words
A method for inhibiting gastric secretion which comprises administering to a subject with gastric hyperacidity an effective antisecretory amount of a (2-amino-2-oxoethoxy)acetic acid compound represented by the formula ##STR30## wherein M is hydrogen, alkali metal, alkaline earth metal, ammonium, alkylammonium or hydroxyalkylammonium; and Z is a radical represented by ##STR31## wherein Ar is phenyl, trifluoromethylphenyl, halo-substituted-phenyl, lower alkyl-substituted-phenyl, or lower alkoxy-substituted-phenyl, said (2-amino-2-oxoethoxy)acetic acid compound being supplied in admixture with a pharmaceutical carrier.
Claim 5
Dependent Claim
43 words
A (2-amino-2-oxoethoxy)acetic acid compound represented by the formula ##STR32## wherein M is hydrogen, alkali metal, alkaline earth metal, ammonium, alkylammonium or hydroxyalkylammonium; and Z is a radical represented by ##STR33## wherein each Ar independently is phenyl, trifluoromethylphenyl, halo-substituted-phenyl, lower alkyl-substituted-phenyl, or lower alkoxy-substituted-phenyl.
Claim 6
Dependent Claim
43 words
A (2-amino-2-oxoethoxy)acetic acid compound represented by the formula ##STR32## wherein M is hydrogen, alkali metal, alkaline earth metal, ammonium, alkylammonium or hydroxyalkylammonium; and Z is a radical represented by ##STR33## wherein each Ar independently is phenyl, trifluoromethylphenyl, halo-substituted-phenyl, lower alkyl-substituted-phenyl, or lower alkoxy-substituted-phenyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 3 which is [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetic acid.
References Cited (Backward Citations)
GB863715A
Cited
US3183069A
Cited
US3379712A
Cited
US3423394A
Cited
US3398151A
Cited
US3699092A
Cited
US3859337A
Cited
US3717634A
Cited
DE2511613A1
Cited
DE2511888A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-30 | 1982-05-01 | 1982-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-30 | 1986-05-01 | 1986-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-30 | 1990-05-01 | 1990-10-31 | $7700.00 | Window Closed / Lapsed |