US4122262A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intermediates and methods for preparing 7-acylamino-8-oxo-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives
Assignee: GlaxoSmithKline LLC
•
Filing: 1977-08-08
•
Granted: 1978-10-24
•
Expires: 1997-08-08
Abstract
Abstract Intermediates and methods for preparing a new series of 7-acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]-octane-2-carboxylic acid derivatives are described. The end product compounds have antibacterial activity especially against certain Gram negative organisms.
Inventors
- 👤 Thomas Francis Buckley
- 👤 John Gerald Gleason
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:30
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07D205/085; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
57 words
A compound of the formula: ##STR6## in which: R 4 is hydrogen or a carboxy protective group susceptible to removal by hydrogenation or hydrolysis with an alkali metal carbonate; R 3 is a saturated or unsaturated, substituted or unsubstituted lower alkyl of 1-4 carbons; X is thio or oxy; and R 5 is amino or blocked amino.
Claim 2
Dependent Claim
57 words
A compound of the formula: ##STR6## in which: R 4 is hydrogen or a carboxy protective group susceptible to removal by hydrogenation or hydrolysis with an alkali metal carbonate; R 3 is a saturated or unsaturated, substituted or unsubstituted lower alkyl of 1-4 carbons; X is thio or oxy; and R 5 is amino or blocked amino.
Claim 3
Dependent Claim
23 words
The compound of claim 1 in which: R 4 is hydrogen; R 3 is methyl; X is oxy; and R 5 is amino.
Claim 4
Dependent Claim
36 words
The compound of claim 1 in which: R 4 is diphenylmethyl; R 3 is methyl; X is oxy; and R 5 is an amino blocked by a group which can be converted to amino by hydrogenation.
Claim 5
Dependent Claim
26 words
The compound of claim 1 in which: R 4 is a carboxyl protective group; R 3 is methyl; X is oxy; and R 5 is amino.
Claim 6
Dependent Claim
24 words
The compound of claim 3 in which R 5 is azido and the configuration at position 4 is α and at 2 is β.
Claim 7
Dependent Claim
8 words
The compound of claim 1 being cis-7-amino-4α-methoxy-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2β-carboxylic acid.
References Cited (Backward Citations)
US4013653A
Cited
US4012383A
Cited
US4011216A
Cited
US4068078A
Cited
US4068080A
Cited
US4068075A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-23 | 1982-04-24 | 1982-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-23 | 1986-04-24 | 1986-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-23 | 1990-04-24 | 1990-10-24 | $7700.00 | Window Closed / Lapsed |