O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents
Abstract
Abstract There is described the stereoselective total synthesis of novel Δ 2 ,3 -1,4-morpholine-2-carboxylic acids possessing a fused β-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acylamino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.
Inventors
- 👤 Marcel Menard
- 👤 Gary M. F. Lim
- 👤 Terry T. Conway
Bibliographic Details
Claims Analysis
Total Claims: 6References Cited (Backward Citations)
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