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US4122255A
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Substituted amides and sulfonamides containing a heterocyclic group having antiinflammatory activity
Assignee: ER Squibb and Sons LLC
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Filing: 1977-09-21
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Granted: 1978-10-24
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Expires: 1997-09-21
Abstract
Abstract Compounds having the formula <IMAGE> wherein R1 is alkyl, cycloalkyl or aryl; R2 is acyl or sulfonyl; R3 is a nitrogen containing heterocyclic group; A1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.
Inventors
- 👤 John Krapcho
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:37
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12; A; A61; A61K; A61K31/00; A61K31/16; A61K31/18; C07C; C07C233/00; C07C233/01; C07C233/12; C07C233/16
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
123 words
A compound having the formula ##STR10## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, cycloalkyl or aryl; R 2 is ##STR11## wherein Y is styryl or styryl substituted in the phenyl ring with a halogen, alkyl, alkoxy, trifluoromethyl, nitro or amino group; R 3 ia 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; and wherein aryl is phenyl or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl, nitro, or amino group; alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 2
Dependent Claim
123 words
A compound having the formula ##STR10## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, cycloalkyl or aryl; R 2 is ##STR11## wherein Y is styryl or styryl substituted in the phenyl ring with a halogen, alkyl, alkoxy, trifluoromethyl, nitro or amino group; R 3 ia 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; and wherein aryl is phenyl or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl, nitro, or amino group; alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 3
Dependent Claim
11 words
A compound in accordance with claim 1 having the formula ##STR12##
Claim 4
Dependent Claim
11 words
A compound in accordance with claim 1 having the formula ##STR13##
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is alkyl.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is aryl.
Claim 7
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 3 is 4-morpholinyl.
Claim 8
Dependent Claim
12 words
A compound in accordance with claim 3 wherein R 3 is 4-morpholinyl.
Claim 9
Dependent Claim
22 words
A compound in accordance with claim 6 wherein A 2 is --(CH 2 ) 2 -- or --(CH 2 ) 3 --.
Claim 10
Dependent Claim
13 words
The compound in accordance with claim 6 having the name N-[[2-[3-(4-morpholinyl)propoxy]phenyl]methyl]-3-phenyl-N-(2-phenylethyl)-2-propenamide, hydrochloride (1:1).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-23 | 1982-04-24 | 1982-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-23 | 1986-04-24 | 1986-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-23 | 1990-04-24 | 1990-10-24 | $7700.00 | Window Closed / Lapsed |