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US4122188A
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US
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Treatment of hyperlipoproteinemia with a dichloroacetate salt
Assignee: Vanderbilt University
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Filing: 1977-08-29
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Granted: 1978-10-24
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Expires: 1997-08-29
Abstract
Abstract The present invention relates to the use of salts of dichloroacetate which contain one or two molecules of dichloroacetate and one or two atoms of a mono- or divalent metallic cation, and particularly sodium dichloroacetate, for the treatment of hyperlipoproteinemia in humans. The method of this invention has utility in the treatment of conditions in a human patient-subject in which there is abnormal elevation of the blood levels of one or more of the major lipids (cholesterol and triglycerides) normally present in the body.
Inventors
- 👤 Peter W. Stacpoole
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:48
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
63 words
The method of treating hyperlipoproteinemia in human patients in need of such treatment comprising adminstering orally to the patient-subject from 240 mgs. to 4000 mgs. per day a non-toxic, non-corrosive salt having the formula: ##STR2## wherein: X is any mono or divalent metallic cation; a is an integer from 1 to 2, inclusive; and b is an integer from 1 to 2, inclusive.
Claim 2
Independent Claim
63 words
The method of treating hyperlipoproteinemia in human patients in need of such treatment comprising adminstering orally to the patient-subject from 240 mgs. to 4000 mgs. per day a non-toxic, non-corrosive salt having the formula: ##STR2## wherein: X is any mono or divalent metallic cation; a is an integer from 1 to 2, inclusive; and b is an integer from 1 to 2, inclusive.
Claim 3
Dependent Claim
13 words
The method according to claim 1 in which said compound is sodium dichloroacetate.
Claim 4
Dependent Claim
24 words
The method according to claim 2 in which said sodium dichloroacetate is administered to said patient-subject in the amount of 800-4000 mgs. per day.
Claim 5
Dependent Claim
24 words
The method according to claim 3 in which said sodium dichloroacetate is administered to said patient-subject in the amount of 1000-4000 mgs. per day.
Claim 6
Dependent Claim
21 words
The method according to claim 2 consisting of the administering of said sodium dichloroacetate to a human patient-subject having familial hypercholesterolemia.
Claim 7
Dependent Claim
22 words
The method according to claim 5 in which approximately 3000 mgs. per day of said sodium dichloroacetate is administered to said patient-subject.
References Cited (Backward Citations)
US3179562A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-23 | 1982-04-24 | 1982-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-23 | 1986-04-24 | 1986-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-23 | 1990-04-24 | 1990-10-24 | $7700.00 | Window Closed / Lapsed |