Cyclic exo amides

Claim 1

A compound selected from the group consisting of a cyclic exoamide of the formula: ##STR47## wherein n has a value of 4 to 8; X is carbonyl; a ketal, thioketal, hemithioketal, oxime, semicarbazone or hydrazone derived from such carbonyl; or C(OH)R in which R is hydrogen or alkyl of 1 to 4 carbon atoms; R 1 is hydrogen, alkyl of 1 to 12 carbon atoms, phenyl, benzyl or toluyl; R 3 is hydroxy, acyloxy of 1 to 4 carbon atoms, or benzyloxy; each of R 2 and R 4 is independently hydrogen, alkyl of 1 to 9 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, phenyl, naphthyl, or alkyl of 1 to 6 carbon atoms substituted with cycloalkyl of 5 to 8 carbon atoms, phenyl or naphthyl, said phenyl and naphthyl being unsubstituted or substituted by up to three substituents selected from the group consisting of fluoro, chloro, bromo, trifluoromethyl, alkyl of 1 to 4 carbon atoms, nitro, and alkoxy of 1 to 4 carbon atoms, or R 2 and R 4 taken together with the carbon atoms to which they are commonly bound are cycloalkyl of 5 to 8 carbon atoms; and R 5 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, and the pharmaceutically acceptable non-toxic salts thereof.