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US4117228A
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1,3-benzodioxol derivatives
Assignee: Eisai Co Ltd
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Filing: 1977-02-18
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Granted: 1978-09-26
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Expires: 1997-02-18
Abstract
Abstract 1,3-Benzodioxol derivatives, the new compounds, represented by the formula: ##STR1## AND THE PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF ARE PROVIDED, WHEREIN R 1 and R 2 are lower alkyls or the both together may form a divalent alkylene, R 3 is a lower alkyl, phenyl, halogen-substituted phenyl or benzhydryl group, n is an integer of 2 or 3, and X stands for carbonyl (CO) or methylene (CH 2 ) bridge. The compounds in which X stands for the methylene exhibit durable anti-histamic activity with low toxicity, and are useful for therapeutic purposes, while the compounds in which X stands for the carbonyl bridge are easily convertible by reduction into the former compounds.
Inventors
- 👤 Satoru Tanaka
- 👤 Hideaki Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 15:29
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
45 words
A member selected from the group consisting of a compound of the formula ##STR62## wherein R 1 and R 2 are respectively lower alkyl of 1-2 carbon atoms and R 3 is methyl, phenyl, chlorophenyl or benzhydryl, and a pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
45 words
A member selected from the group consisting of a compound of the formula ##STR62## wherein R 1 and R 2 are respectively lower alkyl of 1-2 carbon atoms and R 3 is methyl, phenyl, chlorophenyl or benzhydryl, and a pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
20 words
A compound according to claim 1 wherein R 1 is methyl, R 2 is ethyl, and R 3 is benzhydryl.
Claim 4
Dependent Claim
17 words
A compound according to claim 1 wherein R 1 , R 2 adn R 3 are methyl.
Claim 5
Dependent Claim
20 words
A compound according to claim 1 wherein R 1 is methyl, R 2 is methyl and R 3 is p-chlorophenyl.
Claim 6
Dependent Claim
20 words
A compound according to claim 1 wherein R 1 is methyl, R 2 is ethyl and R 3 is p-chlorophenyl.
References Cited (Backward Citations)
US3119826A
Cited
US4010267A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-25 | 1982-03-27 | 1982-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-25 | 1986-03-27 | 1986-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-25 | 1990-03-27 | 1990-09-26 | $7700.00 | Window Closed / Lapsed |