Patent US4115553A successfully refreshed from Google Patents.
US4115553A
Expired / Lapsed
US
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Antacid tablets
Assignee: Reheis Co Inc
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Filing: 1974-06-24
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Granted: 1978-09-19
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Expires: 1994-06-24
Abstract
Abstract Antacid tablets prepared by codrying certain basic aluminum bicarbonate-carbonate compositions with di- or trihydroxy alcohols suitable for oral ingestion, to obtain a powder material, and forming such a material suitably along with tablet forming ingredients into tablets which have superior mouth feel and which yield faster reaction velocities than prior antacid tablets.
Inventors
- 👤 Andrew M. Rubino
- 👤 Jack J. Margres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 13:41
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/06; A61K33/10; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0056
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
146 words
An antacid tablet comprising the codried combination of a hydrous gelatinous aluminum hydroxide material with an alcohol, and an excipient therefor, said material being selected from the group consisting of: (1) basic aluminum bicarbonate-carbonate and (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilioate, or mixtures thereof, said alcohol being a foodgrade di- or trihydroxy alcohol suitable for oral ingestion, wherein analysis of the codried combination yields a figure of from 30 to 60 weight percent for the sum of the aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is present at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , said codried combination being contained in the tablet in an amount of from 10 to 90 weight percent of the tablet.
Claim 2
Dependent Claim
146 words
An antacid tablet comprising the codried combination of a hydrous gelatinous aluminum hydroxide material with an alcohol, and an excipient therefor, said material being selected from the group consisting of: (1) basic aluminum bicarbonate-carbonate and (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilioate, or mixtures thereof, said alcohol being a foodgrade di- or trihydroxy alcohol suitable for oral ingestion, wherein analysis of the codried combination yields a figure of from 30 to 60 weight percent for the sum of the aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is present at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , said codried combination being contained in the tablet in an amount of from 10 to 90 weight percent of the tablet.
Claim 3
Dependent Claim
14 words
The tablet of claim 1 which contains mannitol in addition to said codried combination.
Claim 4
Dependent Claim
16 words
The tablet of claim 1 which contains as a bulking agent and disintegrant a crystalline cellulose.
Claim 5
Dependent Claim
10 words
The tablet of claim 1 wherein said alcohol is glycerin.
Claim 6
Dependent Claim
12 words
The tablet of claim 1 wherein said alcohol is 1:2 propylene glycol.
Claim 7
Dependent Claim
12 words
The tablet of claim 1 wherein said alcohol is 1:3 butylene glycol.
Claim 8
Dependent Claim
121 words
A process for the preparation of antacid tablets comprising codrying a hydrous gelatinous aluminum hydroxide material selected from the group consisting of: (1) basic aluminum bicarbonate-carbonate, and (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, and a foodgrade di- or trihydroxy alcohol suitable for oral ingestion, to obtain a codried combination which yields a figure of from 30 to 60 weight percent for the sum of aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is present at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , and compressing said codried combination into tablets.
Claim 9
Dependent Claim
121 words
A process for the preparation of antacid tablets comprising codrying a hydrous gelatinous aluminum hydroxide material selected from the group consisting of: (1) basic aluminum bicarbonate-carbonate, and (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, and a foodgrade di- or trihydroxy alcohol suitable for oral ingestion, to obtain a codried combination which yields a figure of from 30 to 60 weight percent for the sum of aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is present at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , and compressing said codried combination into tablets.
Claim 10
Dependent Claim
76 words
In a process for the preparation of antacid tablets, the improvement which comprises the step of compressing a powder which is a codried composition of wet aluminum hydroxide gel and a foodgrade di- or trihydroxy alcohol suitable for oral ingestion and which contains from 30 to 60 percent Al 2 O 3 and at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , to form a tablet.
Claim 11
Dependent Claim
76 words
In a process for the preparation of antacid tablets, the improvement which comprises the step of compressing a powder which is a codried composition of wet aluminum hydroxide gel and a foodgrade di- or trihydroxy alcohol suitable for oral ingestion and which contains from 30 to 60 percent Al 2 O 3 and at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , to form a tablet.
Claim 12
Dependent Claim
18 words
The process of claim 7 in which said codried composition contains from 5 to 50 percent foodgrade alcohol.
Claim 13
Dependent Claim
11 words
The process of claim 7 in which said alcohol is glycerin.
Claim 14
Dependent Claim
147 words
An antacid tablet comprising the codried combination of a hydrous gelatinous aluminum hydroxide material with an alcohol, and an excipient therefor, said material being selected from the group consisting of: (1) basic aluminum bicarbonate-carbonate and (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, said alcohol being polyethylene glycol having a molecular weight of about 200 to 700, wherein analysis of the codried combination yields a figure of from 30 to 60 weight percent for the sum of the aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is present at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , said codried combination being contained in the tablet in an amount of from 10 to 90 weight percent of the tablet.
Claim 15
Dependent Claim
147 words
An antacid tablet comprising the codried combination of a hydrous gelatinous aluminum hydroxide material with an alcohol, and an excipient therefor, said material being selected from the group consisting of: (1) basic aluminum bicarbonate-carbonate and (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, said alcohol being polyethylene glycol having a molecular weight of about 200 to 700, wherein analysis of the codried combination yields a figure of from 30 to 60 weight percent for the sum of the aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is present at least 0.3 mole of carbonate calculated as CO 2 for each mole of Al 2 O 3 , said codried combination being contained in the tablet in an amount of from 10 to 90 weight percent of the tablet.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |