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US4115382A
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3,3-Dichloro-2-azetidinone derivatives having basic substituents
Assignee: ER Squibb and Sons LLC
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Filing: 1977-06-06
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Granted: 1978-09-19
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Expires: 1997-06-06
Abstract
Abstract Compounds having the formula ##STR1## wherein X is oxygen or sulfur; R 1 is alkyl, cycloalkyl or aryl; R 2 is dialkylamino or a nitrogen containing heterocyclic group; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.
Inventors
- 👤 John Krapcho
- 👤 Chester F. Turk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:40
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
103 words
A compound having the formula ##STR7## or a pharmaceutically acceptable acid-addition salt thereof, wherein X is oxygen or sulfur; R 1 is alkyl, cycloalkyl or aryl; R 2 is dialkylamino[, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl or 4-alkyl-1-piperazinyl]; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; wherein aryl is phenyl or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl, or nitro group; alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 2
Dependent Claim
103 words
A compound having the formula ##STR7## or a pharmaceutically acceptable acid-addition salt thereof, wherein X is oxygen or sulfur; R 1 is alkyl, cycloalkyl or aryl; R 2 is dialkylamino[, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl or 4-alkyl-1-piperazinyl]; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A 2 is an alkylene group having 2 to 5 carbon atoms; wherein aryl is phenyl or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl, or nitro group; alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 3
Dependent Claim
11 words
A compound in accordance with claim 1 wherein X is oxygen.
Claim 4
Dependent Claim
11 words
A compound in accordance with claim 1 wherein X is sulfur.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is alkyl.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is aryl.
Claim 7
Dependent Claim
12 words
a compound in accordance with claim 2 wherein R 1 is phenyl.
Claim 8
Dependent Claim
10 words
The compound in accordance with claim 1, 3,3-dichloro-1-[2-[3-(dimethylamino)propoxy]phenyl]-4-[3-(trifluoromethyl)phenyl]-2-azetidinone, hydrochloride (1:1).
Claim 9
Dependent Claim
10 words
The compound in accordance with claim 1, 3,3-dichloro-1-[2-[[3-(dimethylamino)propyl]thio]phenyl]-4-phenyl-2-azetidinone, hydrochloride (1:1).
References Cited (Backward Citations)
US3194801A
Cited
US3481920A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |