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Patent US4115198A successfully refreshed from Google Patents.
US4115198A
Expired / Lapsed
US
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Method of immobilization of biologically active organic substances including enzymes
Assignee: Individual
•
Filing: 1976-07-08
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Granted: 1978-09-19
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Expires: 1996-07-08
Abstract
Abstract Insoluble supports are preactivated by precipitating thereon a hydrous metal oxide employing a hydrolysis reaction of a salt of said metal in the presence of said insoluble support. The resulting composite materials are employed as supports for immobilizing biologically active substances.
Inventors
- 👤 Robert W. Coughlin
- 👤 Marvin Charles
- 👤 Billy R. Allen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/141; A61K9/143; A61K39/00; A61K39/395; A61K39/44; A61K9/20; A61K9/2004; A61K9/2009; C; C12; C12N; C12N11/00; C12N11/14; C12P; C12P19/00; C12P19/14; C12P19/20; Y; Y02; Y02P; Y02P20/00; Y02P20/50
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
82 words
A method of preparing water-insoluble enzymes comprising the steps: (a) precipitating a hydrous metal oxide from a solution of a salt of said metal in the presence of an insoluble support material so as to form a coating of the said oxide on the said support, (b) washing the composite support material resulting from step a, (c) contacting the composite support material resulting from step b with a solution of an enzyme so as to immobilize said enzyme on said support material.
Claim 2
Independent Claim
82 words
A method of preparing water-insoluble enzymes comprising the steps: (a) precipitating a hydrous metal oxide from a solution of a salt of said metal in the presence of an insoluble support material so as to form a coating of the said oxide on the said support, (b) washing the composite support material resulting from step a, (c) contacting the composite support material resulting from step b with a solution of an enzyme so as to immobilize said enzyme on said support material.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein the mixture resulting from steps a and b is heated after the washing step b.
Claim 4
Dependent Claim
19 words
The method of claim 2 wherein the precipitation is accomplished by hydrolysis of a salt of the said metal.
Claim 5
Dependent Claim
24 words
The method of claim 3 wherein the said metal is chosen from the group consisting of Ti, Sn, Zr, Al, Fe, V and Hf.
Claim 6
Dependent Claim
9 words
Water-insoluble enzymes produced by the method of claim 2.
Claim 7
Dependent Claim
9 words
Water-insoluble enzymes produced by the method of claim 3.
Claim 8
Dependent Claim
9 words
Water-insoluble enzymes produced by the method of claim 4.
Claim 9
Dependent Claim
9 words
Water-insoluble enzymes produced by the method of claim 1.
Claim 10
Dependent Claim
21 words
Water-insoluble enzymes according to claim 8 wherein the enzymes are chosen from the group consisting of lactase, amyloglucosidase and glucose isomerase.
References Cited (Backward Citations)
US3783101A
Cited
US3912593A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |