US4113728A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Substituted benzisothiazolones
Assignee: Beecham Group PLC
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Filing: 1976-11-02
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Granted: 1978-09-12
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Expires: 1996-11-02
Abstract
Abstract A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
Inventors
- 👤 Keith Howard Baggaley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 19:28
CPC Classifications
C; C07; C07D; C07D417/00; C07D417/02; C07D417/06; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/435; A61K31/44; A61K31/445; A61K31/47; C07D275/00; C07D275/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
114 words
A compound of the formula ##STR25## or a pharmaceutically acceptable non-toxic acid addition salt thereof when there is a basic nitrogen in the molecule wherein R 1 and R 2 are the same or different and each is hydrogen, alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms, trifluoromethyl, nitro, amino, acetylamino or halogen, or R 1 and R 2 when attached to adjacent carbon atoms form an alkylene moiety of 3 to 6 carbon atoms or an oxy-alkyleneoxy moiety of 1 to 3 carbon atoms; Y is straight- or branched-chain alkylene of 1 to 12 carbon atoms, and R 6 is 3-azabicyclo [3.2.2]non-3-yl, 9-azabicyclo[3.3.1]non-9-yl, 2-azabicyclo[2.2.2]oct-2-yl, 1,2-benzisothiazol-3-on-2-yl, or tetrahydroisoquinolyl.
Claim 2
Dependent Claim
114 words
A compound of the formula ##STR25## or a pharmaceutically acceptable non-toxic acid addition salt thereof when there is a basic nitrogen in the molecule wherein R 1 and R 2 are the same or different and each is hydrogen, alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms, trifluoromethyl, nitro, amino, acetylamino or halogen, or R 1 and R 2 when attached to adjacent carbon atoms form an alkylene moiety of 3 to 6 carbon atoms or an oxy-alkyleneoxy moiety of 1 to 3 carbon atoms; Y is straight- or branched-chain alkylene of 1 to 12 carbon atoms, and R 6 is 3-azabicyclo [3.2.2]non-3-yl, 9-azabicyclo[3.3.1]non-9-yl, 2-azabicyclo[2.2.2]oct-2-yl, 1,2-benzisothiazol-3-on-2-yl, or tetrahydroisoquinolyl.
Claim 3
Dependent Claim
23 words
A compound according to claim 1 wherein R 1 and R 2 are each hydrogen, lower alkyl, lower alkoxy, halo-lower alkyl or halogen.
Claim 4
Dependent Claim
21 words
A compound according to claim 2 wherein R 1 and R 2 are each hydrogen, lower alkyl, lower alkoxy or halogen.
Claim 5
Dependent Claim
18 words
A compound according to claim 1 wherein R 1 and R 2 are in the 5-and 6- positions.
Claim 6
Dependent Claim
14 words
The compound according to claim 1 which is 2-[6-(3-azabicyclo[3.2.2]non-3-yl)-hexyl]-1,2-benzisothiazlol-3-one or the hydrochloride salt thereof.
Claim 7
Dependent Claim
28 words
The compound according to claim 1 of the formula ##STR26## wherein R 1 and R 2 are each hydrogen and R is 3-azabicyclo[3.2.2]-non-3-yl, or the hydrochloride salt thereof.
Claim 8
Dependent Claim
23 words
The compound according to claim 1 of the formula ##STR27## wherein R 1 and R 2 are each chloro and R is 3-azabicyclo[3.2.2]-non-3-yl.
Claim 9
Dependent Claim
28 words
The compound according to claim 1 of the formula ##STR28## wherein R 1 and R 2 are each methoxy and R is 3-azabicyclo[3.2.2]-non-3-yl, or the hydrochloride salt thereof.
Claim 10
Dependent Claim
28 words
The compound according to claim 1 of the formula ##STR29## wherein R 1 and R 2 are each hydrogen and R is N-1,2,3,4-tetrahydroisoquinolyl, or the hydrochloride salt thereof.
Claim 11
Dependent Claim
23 words
The compound according to claim 1 of the formula ##STR30## wherein R 1 and R 2 are each hydrogen and R is 1,2-benzisothiazol-3-on-2-yl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-11 | 1982-03-13 | 1982-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-11 | 1986-03-13 | 1986-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-11 | 1990-03-13 | 1990-09-12 | $7700.00 | Window Closed / Lapsed |