Patent US4113713A successfully refreshed from Google Patents.
US4113713A
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Method for cleaving the peptide-resin bond in solid phase peptide synthesis by hydrogenolysis
Assignee: GD Searle LLC
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Filing: 1977-06-16
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Granted: 1978-09-12
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Expires: 1997-06-16
Abstract
Abstract An improved process for cleaving peptides bound to a polymer by way of a benzylester linkage during solid phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using a palladium (II) salt with a weak acid anion as the catalyst.
Inventors
- 👤 James M. Schlatter
- 👤 Owen Goodmonson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:24
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/12
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
43 words
In a process for cleaving peptides bound to a polymer by way of benzylester linkage during solid phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using a palladium (II) salt with a weak acid anion as the catalyst.
Claim 2
Dependent Claim
43 words
In a process for cleaving peptides bound to a polymer by way of benzylester linkage during solid phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using a palladium (II) salt with a weak acid anion as the catalyst.
Claim 3
Dependent Claim
37 words
In a process for cleaving peptides bound to a polymer by way of a benzylester linkage during phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using palladium (II) acetate as the catalyst.
Claim 4
Dependent Claim
37 words
In a process for cleaving peptides bound to a polymer by way of a benzylester linkage during phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using palladium (II) acetate as the catalyst.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-11 | 1982-03-13 | 1982-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-11 | 1986-03-13 | 1986-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-11 | 1990-03-13 | 1990-09-12 | $7700.00 | Window Closed / Lapsed |