Patent US4112119A successfully refreshed from Google Patents.
US4112119A
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Method for alleviating angiotensin related hypertension
Assignee: ER Squibb and Sons LLC
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Filing: 1977-03-03
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Granted: 1978-09-05
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Expires: 1997-03-03
Abstract
Abstract A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
Inventors
- 👤 Miguel Angel Ondetti
- 👤 David W. Cushman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 05:16
CPC Classifications
C; C07; C07C; C07C319/00; C07C319/14; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
77 words
A method for alleviating angiotensin related hypertension in hypertensive mammals which comprises administering to said mammals an effective dose of an angiotensin converting enzyme inhibitor having the formula ##STR12## or salt thereof, wherein R 1 is amino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene or carboxy-lower alkylene; R 2 , r 3 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkylene; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR13## n is 0, 1 or 2.
Claim 2
Independent Claim
77 words
A method for alleviating angiotensin related hypertension in hypertensive mammals which comprises administering to said mammals an effective dose of an angiotensin converting enzyme inhibitor having the formula ##STR12## or salt thereof, wherein R 1 is amino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene or carboxy-lower alkylene; R 2 , r 3 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkylene; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR13## n is 0, 1 or 2.
Claim 3
Dependent Claim
21 words
A method as in claim 1 wherein the compound has the L-configuration with respect to the carbon bearing R 1 .
Claim 4
Dependent Claim
19 words
A method as in claim 2 wherein the dosage is about 10 to 500 mg. per kilogram per day.
Claim 5
Dependent Claim
30 words
A method as in claim 1 wherein in the formula the group ##STR14## is derived from an amino acid of the group consisting of lysine, cysteine, methionine and aspartic acid.
Claim 6
Dependent Claim
32 words
A method as in claim 1 wherein in the formula R 1 is aminobutyl, R 2 , R 3 , R 4 and R 5 each is hydrogen and n is 1.
Claim 7
Dependent Claim
32 words
A method as in claim 1 wherein in the formula R 1 is mercaptomethyl, R 2 , R 3 , R 4 and R 5 each is hydrogen and n is 1.
Claim 8
Dependent Claim
32 words
A method as in claim 1 wherein in the formula R 1 is 2-methylthioethyl, R 2 , R 3 , R 4 and R 5 each is hydrogen and n is 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-04 | 1982-03-06 | 1982-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-04 | 1986-03-06 | 1986-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-04 | 1990-03-06 | 1990-09-05 | $7700.00 | Window Closed / Lapsed |