Patent US4112106A successfully refreshed from Google Patents.
US4112106A
Expired / Lapsed
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N-(2-thiazolyl)-tetrazole-5-carboxamide derivatives for the prevention of immediate type hypersensitivity reactions
Assignee: Wyeth LLC
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Filing: 1977-07-15
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Granted: 1978-09-05
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Expires: 1997-07-15
Abstract
Abstract Anti-allergic agents of N-(2-thiazolyl)-1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R is hydrogen, lower alkyl, lower alkoxy, --CN, (lower)alkyl amino, di(lower) alkylamino, polyhalo(lower)alkyl, halo and carbamoyl; Or a pharmaceutically acceptable salt thereof.
Inventors
- 👤 John H. Sellstedt
- 👤 Charles J. Guinosso
- 👤 Albert J. Begany
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:30
CPC Classifications
C; C07; C07D; C07D257/00; C07D257/02; C07D257/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
88 words
A process for preventing the release of pharmacological mediators from an immediate hypersensitivity reaction between reaginic type antibodies and an antigen, thereby preventing the symptoms manifest in bronchial asthma, seasonal pollinosis, allergic rhinitis, urticaria, allergic conjunctivitis, food allergy and anaphylactoid reactions of a sensitized animal, which comprises prophylactically administering to said animal an effective amount of a compound of the formula: ##STR6## in which R is hydrogen, lower alkyl, lower alkoxy, --CN, (lower) alkyl amino, di(lower) alkylamino, polyhalo(lower) alkyl, halo and carbamoyl; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
88 words
A process for preventing the release of pharmacological mediators from an immediate hypersensitivity reaction between reaginic type antibodies and an antigen, thereby preventing the symptoms manifest in bronchial asthma, seasonal pollinosis, allergic rhinitis, urticaria, allergic conjunctivitis, food allergy and anaphylactoid reactions of a sensitized animal, which comprises prophylactically administering to said animal an effective amount of a compound of the formula: ##STR6## in which R is hydrogen, lower alkyl, lower alkoxy, --CN, (lower) alkyl amino, di(lower) alkylamino, polyhalo(lower) alkyl, halo and carbamoyl; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
32 words
A compound of the formula: ##STR7## in which R is hydrogen, lower alkyl, lower alkoxy, --CN, (lower) alkyl amino, di(lower) alkylamino, polyhalo(lower) alkyl, halo and carbamoyl; or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
32 words
A compound of the formula: ##STR7## in which R is hydrogen, lower alkyl, lower alkoxy, --CN, (lower) alkyl amino, di(lower) alkylamino, polyhalo(lower) alkyl, halo and carbamoyl; or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
14 words
A compound of claim 2 which is N-(2-thiazolyl)-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
14 words
A compound of claim 2 which is N-(5-chloro-2-thiazolyl)-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
14 words
A compound of claim 2 which is N-(4-cyano-2-thiazolyl)-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
14 words
A compound of claim 2 which is N-(4-dimethylamino-2-thiazolyl)-1H-tetrazole-5-carboxamide or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
USRE27506E
Cited
US3957812A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-04 | 1982-03-06 | 1982-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-04 | 1986-03-06 | 1986-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-04 | 1990-03-06 | 1990-09-05 | $7700.00 | Window Closed / Lapsed |