Pyrazolo(1,5-c)quinazoline derivatives and related compounds

Claim 1

A compound of the structure ##STR541## wherein R 1 and R 2 are the same or different, and R 1 is selected from the group consisting of hydrogen, lower alkyl, phenyl, phenyl having a single substituent selected from the group consisting of halogen, lower alkyl, lower alkoxy, and trifluoromethyl, or ##STR542## R 2 is selected from the group consisting of ##STR543## hydrogen, lower alkyl, phenyl or phenyl having a single substituent selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl, with the proviso that at least one of R 1 and R 2 is ##STR544## R 6 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbons, mono-halophenyl, mono-lower alkoxyphenyl, phenylalkyl having 1 to 8 carbons in the alkyl group, phenyl, or phenyl having a mono-lower alkoxy substituent; R 3 is selected from the group consisting of hydrogen, lower alkyl, benzyl, phenyl, phenyl having a single substituent selected from the group consisting of lower alkoxy, trifluoromethyl, benzyl, or benzyl having a single substituent selected from the group consisting of lower alkoxy, halogen or trifluoromethyl; R 4 and R 5 are the same or different and are selected from the group consisting of hydrogen, alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, lower alkanoyloxy of 1 to 4 carbons, nitro, benzyloxy, benzyloxy having a mono-lower alkoxy substituent, halogen, hydroxy, and trifluoromethyl; R 7 and R 8 may be the same or different and are selected from the group consisting of hydrogen, alkyl having 1 to 3 carbons, phenyl, phenyl having a lower alkoxy substituent, benzyl, or benzyl having a mono-lower alkoxy substituent, or R 7 and R 8 taken together is a single cycloalkyl ring of 3 to 7 carbons; (CH 2 ) m and (CH 2 ) n represent straight chain alkylene radicals, or mono- or di-alkyl substituted alkylene radicals wherein the alkyl group has 1 to 2 carbons, m and n are integers which may be the same or different and are 0 to 10, with the proviso that m + n is ≦ 10, and where m is 0, (CH 2 ) m represents a single bond or where n is 0, (CH 2 ) n represents a single bond, and physiologically acceptable salts thereof.