Triazoloquinazolines
Abstract
Abstract Triazoloquinazolines of the formula, ##STR1## wherein R 1 is C 1 -4 alkyl or aryl; R 2 and R 3 are independently hydrogen, halogen, trifluoromethyl, nitro, C 1 -4 alkyl or C 1 -4 alkoxy, or R 2 and R 3 together may form methylenedioxy; and R 4 is hydrogen, C 1 -4 alkyl, aralkyl, C 1 -4 haloalkyl, or C 3 -6 cycloalkyl; and pharmaceutically acceptable acid addition salts thereof are prepared by (a) reacting a 2-hydrazinoquinazoline derivative with a carboxylic acid or reactive derivative thereof, (b) cyclizing a 2-acylhydrazinoquinazoline derivative with heating or (c) reacting a triazolylbenzophenone derivative with ammonia. Said triazoloquinazolines and pharmaceutically acceptable acid addition salts thereof show excellent anti-inflammatory and analgesic activities.
Inventors
- 👤 Michihiro Yamamoto
- 👤 Shigeaki Morooka
- 👤 Masao Koshiba
- 👤 Shigeho Inaba
- 👤 Hisao Yamamoto
Bibliographic Details
Claims Analysis
Total Claims: 12References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1980-01-11 | 1980-07-12 | 1981-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-11 | 1984-07-12 | 1985-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-11 | 1988-07-12 | 1989-01-11 | $7700.00 | Window Closed / Lapsed |