Patent US4110442A successfully refreshed from Google Patents.
US4110442A
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2-phosphonoxy-4-trifluoromethylbenzoic acid derivatives and pharmaceutical compositions containing same
Assignee: Noucor Health SA
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Filing: 1976-12-30
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Granted: 1978-08-29
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Expires: 1996-12-30
Abstract
Abstract 2-OR-4-trifluoromethylbenzoic acid wherein R is phosphonoxy. The compounds are useful in the treatment of pathological cardiovascular conditions, particularly in the prophylaxis of the thromboembolic diseases. The compounds are made by reacting m-trifluoromethyl phenol with potassium carbonate and carbon dioxide at an elevated temperature and pressure and, reacting the 2-OH compound with a phosphonating agent. The invention also embraces pharmaceutical compositions in which the compounds constitute the effective agent and a method of treatment.
Inventors
- 👤 Emilia F. Barsa
- 👤 Antonio C. Marin Moga
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 16:26
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/12; A; A61; A61P; A61P7/00; A61P7/02; C07C; C07C51/00; C07C51/15
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
16 words
The compound of the formula ##STR5## in which R is phosphonoxy, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
16 words
The compound of the formula ##STR5## in which R is phosphonoxy, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
38 words
The method for the treatment and prophylaxis of a cardiovascular condition due to platelet aggregation, coagulation and fibrinolysis, the said method comprising the by oral administration per day of 200-300 mg of the effective agent of claim 1.
Claim 4
Dependent Claim
31 words
A pharmaceutical composition for the treatment and prophylaxis of cardiovascular conditions due to platelet aggregation coagulation and fibrinolysis comprising a carrier and the compound of claim 1 as the effective agent.
Claim 5
Dependent Claim
27 words
The composition of claim 3 which is in the form of a capsule, tablet, dragee or suppository and includes 200--300 mg of the effective agent per unit.
Claim 6
Dependent Claim
25 words
The composition of claim 3 which is in the form of a syrup and includes about 4-5 g of the effective agent per 100 ml.
References Cited (Backward Citations)
CA621838A
Cited
US3019253A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-28 | 1982-02-27 | 1982-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-28 | 1986-02-27 | 1986-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-28 | 1990-02-27 | 1990-08-29 | $7700.00 | Window Closed / Lapsed |