US4108989A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones
Assignee: GlaxoSmithKline LLC
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Filing: 1977-04-01
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Granted: 1978-08-22
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Expires: 1997-04-01
Abstract
Abstract Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.
Inventors
- 👤 Kenneth George Holden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 02:54
CPC Classifications
C; C07; C07D; C07D223/00; C07D223/14; C07D223/16; C07C; C07C45/00; C07C45/61; C07C45/63; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C47/00; C07C47/52; C07C47/575
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
81 words
A compound of the formula: ##STR3## in which: R is hydrogen or halo; R 1 is lower alkyl having from 1 to 5 carbon atoms, lower alkanoyl having from 1 to 5 carbon atoms, benzyl, phenethyl, carbobenzyloxy, or hydroxyethyl; and R 2 is phenyl, or phenyl which is optionally substituted with a lower alkyl having from 1 to 5 carbon atoms, halo, lower alkoxy having from 1 to 4 carbon atoms, hydroxy or thiomethyl; and the pharmaceutically acceptable nontoxic salts thereof.
Claim 2
Dependent Claim
81 words
A compound of the formula: ##STR3## in which: R is hydrogen or halo; R 1 is lower alkyl having from 1 to 5 carbon atoms, lower alkanoyl having from 1 to 5 carbon atoms, benzyl, phenethyl, carbobenzyloxy, or hydroxyethyl; and R 2 is phenyl, or phenyl which is optionally substituted with a lower alkyl having from 1 to 5 carbon atoms, halo, lower alkoxy having from 1 to 4 carbon atoms, hydroxy or thiomethyl; and the pharmaceutically acceptable nontoxic salts thereof.
Claim 3
Dependent Claim
17 words
The compound of claim 1 in which R is hydrogen and R 1 is hydrogen or methyl.
Claim 4
Dependent Claim
18 words
The compound of claim 2 in which R and R 1 are hydrogen and R 2 is phenyl.
Claim 5
Dependent Claim
13 words
The compound of claim 3 in which the salt form is the hydrobromide.
Claim 6
Dependent Claim
23 words
A pharmaceutical composition in dosage unit form having dopaminergic activity comprising an effective therefor but nontoxic quantity of the compound of claim 1.
Claim 7
Dependent Claim
28 words
The method of producing dopaminergic activity in an animal in need of such activity which comprises administering internally a nontoxic sufficient amount of the compound of claim 1.
References Cited (Backward Citations)
US3393192A
Cited
GB1118688A
Cited
CH555831A
Cited
US3686167A
Cited
US4011319A
Cited
US4052506A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-21 | 1982-02-20 | 1982-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-21 | 1986-02-20 | 1986-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-21 | 1990-02-20 | 1990-08-22 | $7700.00 | Window Closed / Lapsed |