Patent US4102889A successfully refreshed from Google Patents.
US4102889A
Expired / Lapsed
US
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1,2,4-Triazoles
Assignee: Merck and Co Inc
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Filing: 1976-11-09
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Granted: 1978-07-25
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Expires: 1996-11-09
Abstract
Abstract Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricemic agents. Compositions useful in the treatment of gout and hyperuricemia containing a substituted triazole as the active ingredient are also provided.
Inventors
- 👤 John J. Baldwin
- 👤 Frederick C. Novello
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:44
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/14; C07D401/02; C07D401/04; C07D403/00; C07D403/14; C07D405/00; C07D405/02; C07D405/04; C07D409/00; C07D409/14
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
46 words
A compound of the formula ##STR5## and the amine oxides and non-toxic salts thereof, wherein R 1 is hydrogen, lower alkyl, lower alkanoyl, benzyl, carbamoyl or di- lower alkylcarbamoyl; R 3 is napthyl, halophenyl, dihalophenyl, aminophenyl, diloweralkylaminophenyl, loweralkanoylaminophenyl, monoloweralkoxyphenyl, or diloweralkoxyphenyl and R 5 is pyridyl.
Claim 2
Dependent Claim
46 words
A compound of the formula ##STR5## and the amine oxides and non-toxic salts thereof, wherein R 1 is hydrogen, lower alkyl, lower alkanoyl, benzyl, carbamoyl or di- lower alkylcarbamoyl; R 3 is napthyl, halophenyl, dihalophenyl, aminophenyl, diloweralkylaminophenyl, loweralkanoylaminophenyl, monoloweralkoxyphenyl, or diloweralkoxyphenyl and R 5 is pyridyl.
Claim 3
Dependent Claim
23 words
A compound of the formula: ##STR6## and the non-toxic salts thereof; wherein R 8 is halophenyl or dihalophenyl and R 9 is pyridyl.
Claim 4
Dependent Claim
23 words
A compound of the formula: ##STR6## and the non-toxic salts thereof; wherein R 8 is halophenyl or dihalophenyl and R 9 is pyridyl.
Claim 5
Dependent Claim
13 words
A compound of claim 2 selected from 5-(4-pyridyl)-3-(3,4-dichlorophenyl)-1,2,4-triazole, 5-(4-pyridyl)-3-(m-chlorophenyl)-1,2,4-triazole, 5-(4-pyridyl)-3-(3,5-dichlorophenyl)-1,2,4-triazole, 5-(4-pyridyl)-3-(p-bromophenyl)-1,2,4-triazole, or 5-(4-pyridyl)-3-(p-chlorophenyl)-1,2,4-triazole.
Claim 6
Dependent Claim
19 words
A compound selected from N-methyl-4-[2-(p-chlorophenyl)-1,2,4-triazolyl-5]-pyridinium iodide, 1-methyl-3-(p-chlorophenyl-5-(4-pyridyl)-1,2,4-triazole, 3-(p-aminophenyl)-5-(4-pyridyl)-1,2,4-triazole, 3-(p-acetylaminophenyl)-5-(4-pyridyl)-1,2,4-triazole, 1-butyryl-3-(p-chlorophenyl)-5-(4-pyridyl)-1,2,4-triazole, N-methyl-4-[3-(m-chlorophenyl)-1,2,4-triazolyl-5] pyridinium iodide, 1-methyl-3-(p chlorophenyl)-5-(3-pyridyl)1,2,4-triazole, 3-(p-dimethylaminophenyl)-5-(4-pyridyl)-1,2,4-triazole, 1-acetyl-3-(3-dichlorophenyl)-5-(4-pyridyl-1,2,4-triazole, or 1-methyl-3-(3,5-dimethoxyphenyl)-5-(4-pyridyl)-1,2,4-triazole.
Claim 7
Dependent Claim
19 words
A compound selected from N-methyl-4-[2-(p-chlorophenyl)-1,2,4-triazolyl-5]-pyridinium iodide, 1-methyl-3-(p-chlorophenyl-5-(4-pyridyl)-1,2,4-triazole, 3-(p-aminophenyl)-5-(4-pyridyl)-1,2,4-triazole, 3-(p-acetylaminophenyl)-5-(4-pyridyl)-1,2,4-triazole, 1-butyryl-3-(p-chlorophenyl)-5-(4-pyridyl)-1,2,4-triazole, N-methyl-4-[3-(m-chlorophenyl)-1,2,4-triazolyl-5] pyridinium iodide, 1-methyl-3-(p chlorophenyl)-5-(3-pyridyl)1,2,4-triazole, 3-(p-dimethylaminophenyl)-5-(4-pyridyl)-1,2,4-triazole, 1-acetyl-3-(3-dichlorophenyl)-5-(4-pyridyl-1,2,4-triazole, or 1-methyl-3-(3,5-dimethoxyphenyl)-5-(4-pyridyl)-1,2,4-triazole.
Claim 8
Dependent Claim
26 words
A compound having the formula ##STR7## and the amine oxides and nontoxic salts thereof wherein R 3 is mono- or di-loweralkoxyphenyl and R 5 is pryidyl.
Claim 9
Dependent Claim
26 words
A compound having the formula ##STR7## and the amine oxides and nontoxic salts thereof wherein R 3 is mono- or di-loweralkoxyphenyl and R 5 is pryidyl.
Claim 10
Dependent Claim
10 words
A compound of claim 5 selected from 3-(3,5-dimethoxyphenyl)-5-(4-pyridyl)-1,2,4-triazole or 3-(p-methoxyphenyl)-5-(3-pyridyl)-1,2,4-triazole.
References Cited (Backward Citations)
US3515723A
Cited
US3879404A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-24 | 1982-01-23 | 1982-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-24 | 1986-01-23 | 1986-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-24 | 1990-01-23 | 1990-07-25 | $7700.00 | Window Closed / Lapsed |