Patent US4100292A successfully refreshed from Google Patents.
US4100292A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-[N-phenyl-N-(cycloalkyl-methyl)-amino]-2-imidazolines and salts thereof
Assignee: Boehringer Ingelheim GmbH
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Filing: 1977-08-12
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Granted: 1978-07-11
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Expires: 1997-08-12
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1, R2 and R3, which may be identical or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy, hydroxyl, trifluoromethyl or cyano; and R4 is (cycloalkyl of 3 to 6 carbon atoms)-methyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as analgesics.
Inventors
- 👤 Helmut Stahle
- 👤 Herbert Koppe
- 👤 Werner Kummer
- 👤 Klaus Stockhaus
- 👤 Wolfgang Hoefke
- 👤 Franz Josef Kohn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 04:12
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/44; C07D233/50; A; A61; A61P; A61P25/00; A61P25/04
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
45 words
A compound of the formula ##STR67## wherein R 1 , R 2 and R 3 are hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy, trifluoromethyl or cyano; and R 4 is (cycloalkyl of 3 to 6 carbon atoms)-methyl; and non-toxic, pharmacologically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
45 words
A compound of the formula ##STR67## wherein R 1 , R 2 and R 3 are hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy, trifluoromethyl or cyano; and R 4 is (cycloalkyl of 3 to 6 carbon atoms)-methyl; and non-toxic, pharmacologically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
17 words
A compound of claim 1, which is 2-[N-(2,6-dichloro-phenyl)-N-(cyclopropyl-methyl)-amino]-2-imidazoline or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
24 words
An analgesic pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective analgesic amount of a compound of claim 1.
Claim 5
Dependent Claim
29 words
The method of relieving pain in a warm-blooded animal, which comprises perorally, parenterally or rectally administering to said animal an effective analgesic amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-10 | 1982-01-09 | 1982-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-10 | 1986-01-09 | 1986-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-10 | 1990-01-09 | 1990-07-11 | $7700.00 | Window Closed / Lapsed |