US4100170A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anorectic adamantane derivatives and method of using the same
Assignee: AstraZeneca AB
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Filing: 1971-08-13
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Granted: 1978-07-11
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Expires: 1991-08-13
Abstract
Abstract Adamantane derivatives such as beta -(1-adamantyl)- alpha , alpha -dimethylethylamine hydrochloride, beta -(1-adamantyl)- alpha -methylethylamine hydrochloride, d- beta -(1-adamantyl)- alpha -methylethylamine hydrochloride, and 1- beta -(1-adamantyl)- alpha -methylethylamine hydrochloride have anorectic activity.
Inventors
- 👤 Bola Vithal Shetty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 04:19
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/02; C07D295/027; C07D295/03
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
221 words
The method of curbing appetite in an animal which comprises administering to the animal an amount effective to curb appetite of a compound of the formula: ##STR11## or their pharmaceutically acceptable acid addition salts, in which R 1 = H, lower alkyl, aralkyl, aralkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, NO 2 ; phenoxy alkyl or phenoxyalkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, or NO 2 ; acyl including formyl or acetyl; R 2 = h, lower alkyl, COO-lower alkyl, aralkyl, aralkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, NO 2 ; phenoxyalkyl or phenoxyalkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, or NO 2 ; acyl including formyl or acetyl, R 3 = h, lower alkyl or alkynyl; R 4 = h, lower alkyl, or alkynyl; R 5 = h, oh, halogen, or lower alkyl; R 6 = h, oh, halogen, or lower alkyl; or R 5 and R 6 together represent a carbonyl oxygen; R 7 = h, lower alkyl, halogen, hydroxy, alkoxy, amino or substituted amino, trifluoromethyl, sulfamyl, nitro, phenyl; R 8 , r 9 , r 10 , r 11 , r 12 are any of R 7 ; n = 0 to 4; m = 0 to 4;
Claim 2
Independent Claim
221 words
The method of curbing appetite in an animal which comprises administering to the animal an amount effective to curb appetite of a compound of the formula: ##STR11## or their pharmaceutically acceptable acid addition salts, in which R 1 = H, lower alkyl, aralkyl, aralkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, NO 2 ; phenoxy alkyl or phenoxyalkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, or NO 2 ; acyl including formyl or acetyl; R 2 = h, lower alkyl, COO-lower alkyl, aralkyl, aralkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, NO 2 ; phenoxyalkyl or phenoxyalkyl substituted with NH 2 , OH, OCH 3 , halogen, alkyl, or NO 2 ; acyl including formyl or acetyl, R 3 = h, lower alkyl or alkynyl; R 4 = h, lower alkyl, or alkynyl; R 5 = h, oh, halogen, or lower alkyl; R 6 = h, oh, halogen, or lower alkyl; or R 5 and R 6 together represent a carbonyl oxygen; R 7 = h, lower alkyl, halogen, hydroxy, alkoxy, amino or substituted amino, trifluoromethyl, sulfamyl, nitro, phenyl; R 8 , r 9 , r 10 , r 11 , r 12 are any of R 7 ; n = 0 to 4; m = 0 to 4;
Claim 3
Dependent Claim
16 words
The method of claim 1 in which the compound is β-(1-adamantyl)-α,α-dimethylethylamine or its acid addition salt.
Claim 4
Dependent Claim
16 words
The method of claim 1 in which the compound is β-(1-adamantyl)-α-methylethylamine or its acid addition salt.
Claim 5
Dependent Claim
16 words
The method of claim 1 in which the compound is d-β-(1-adamantyl)-α-methylethylamine or its acid addition salt.
Claim 6
Dependent Claim
16 words
The method of claim 1 in which the compound is 1-β-(1-adamantyl)-α-methylethylamine or its acid addition salt.
References Cited (Backward Citations)
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Cited
US3270036A
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US3489802A
Cited
US3501511A
Cited
US3929888A
Cited
US4027035A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-10 | 1982-01-09 | 1982-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-10 | 1986-01-09 | 1986-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-10 | 1990-01-09 | 1990-07-11 | $7700.00 | Window Closed / Lapsed |