US4027035A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic uses of adamantanealkylamine compounds
Assignee: Eli Lilly and Co
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Filing: 1975-08-28
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Granted: 1977-05-31
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Expires: 1995-08-28
Abstract
Abstract 2-Phenyl adamantane alkyl amines are useful as antidepressants and anti-Parkinsonism agents, and may be prepared by a Friedel Crafts synthesis involving reaction of benzene with corresponding 2-halogeno compounds.
Inventors
- 👤 Colin H. Cashin
- 👤 Jiban K. Chakrabarti
- 👤 Stephen S. Szinai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 19:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; C; C07; C07C; C07C2603/00; C07C2603/56; C07C2603/58; C07C2603/70; C07C2603/74
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
113 words
The method for treating a warm-blooded mammal in need of treatment to control depression or Parkinsonism, which comprises administering to the mammal a therapeutically effective amount of an active agent, said active agent being a compound selected from the group consisting of (1) those compounds of the following formula and (2) their pharmaceutically acceptable acid addition salts: ##STR3## wherein each R o independently represents hydrogen or methyl; R 2 represents hydrogen or alkyl of C 1 -C 4 ; and each R 3 independently represents hydrogen, alkyl of C 1 -C 4 , or (2-hydroxy-ethyl), subject to the limitation that at least one of R 2 and R 3 is other than hydrogen.
Claim 2
Independent Claim
113 words
The method for treating a warm-blooded mammal in need of treatment to control depression or Parkinsonism, which comprises administering to the mammal a therapeutically effective amount of an active agent, said active agent being a compound selected from the group consisting of (1) those compounds of the following formula and (2) their pharmaceutically acceptable acid addition salts: ##STR3## wherein each R o independently represents hydrogen or methyl; R 2 represents hydrogen or alkyl of C 1 -C 4 ; and each R 3 independently represents hydrogen, alkyl of C 1 -C 4 , or (2-hydroxy-ethyl), subject to the limitation that at least one of R 2 and R 3 is other than hydrogen.
Claim 3
Dependent Claim
24 words
The method of claim 1 wherein each R o represents hydrogen and R 2 and each R 3 independently represents hydrogen, methyl or ethyl.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the active agent is 2-phenyl-N,N,α-trimethyl-1-adamantaneethylamine hydrochloride.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein the active agent is 2-phenyl-N,α-dimethyl-1-adamantaneethylamine hydrochloride.
References Cited (Backward Citations)
US3270036A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-30 | 1980-11-29 | 1981-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-30 | 1984-11-29 | 1985-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-30 | 1988-11-29 | 1989-05-31 | $7700.00 | Window Closed / Lapsed |