2,6-Methano-3-benzazocines

Claim 1

A compound having the formula ##STR46## where R 1 is hydrogen, lower-alkyl, lower-alkanoyl (only when R 4 is hydrogen), lower-alkenyl, lower-alkynyl, halo-lower-alkenyl, cycloalkyl, cycloalkyl-lower-alkyl, phenyl-lower-alkyl, phenyl-lower-alkyl substituted in the phenyl ring by a single trifluoromethyl or by from one to two members of the group consisting of halogen, lower-alkyl, hydroxy, lower-alkanoyloxy, lower-alkoxy, lower-alkylmercapto, amino, lower-alkanoyl-amino or a single methylenedioxy attached to adjacent carbon atoms, or R 1 is 2- or 3-furylmethyl or such 2- or 3-furylmethyl substituted on the unsubstituted ring carbon atoms by from one to three methyl groups; R 2 , R 2 ', R 2 " and R 2 '" are each hydrogen, or three of them are hydrogen and the fourth is halogen, lower-alkyl, hydroxy, lower-alkanoyloxy, lower-alkoxy, lower-alkylmercapto, trifluoromethyl, nitro, amino, lower-alkanoylamino, lower-alkoxycarbonylamino or phenyl, or two of the adjacent such groups together are methylenedioxy; R 3 is hydrogen or lower-alkyl; R 4 is hydrogen, lower-alkyl, lower-alkoxy-lower-alkyl, hydroxy-lower-alkyl, lower-alkylthio-lower-alkyl, lower-alkylsulfinyl-lower-alkyl, phenylthio-lower-alkyl, phenylsulfinyl-lower-alkyl, lower-alkenyl or halo-lower-alkyl, or R 3 and R 4 together are divalent lower-alkylene, --(CH 2 ) n --, where n is one of the integers 3 or 4; R 8 is hydrogen or lower-alkyl; and Y is carboxy, cyano, carbo-lower-alkoxy, COR 5 , COO-lower-alkylene-cycloalkyl, COO-lower-alkylene-phenyl, or a group of the formula: ##STR47## where R 5 and R 6 are the same or different members selected from the group consisting of hydrogen, lower-alkyl, cycloalkyl-lower-alkyl, phenyl or phenyl-lower-alkyl; and R 7 is hydrogen, lower-alkanoyl, benzoyl, or benzoyl substituted by a single trifluoromethyl or by one to three sterically compatible members of the group consisting of lower-alkyl, lower-alkoxy, hydroxy or halo, and wherein cycloalkyl, all occurrences, is a group having from 3 to 7 carbon atoms or is alkyl-substituted cycloalkyl having a total of from 3 to 8 carbon atoms, 3 to 7 of which are cycloalkyl ring carbon atoms, or an acid-addition salt thereof.