US4097606A
Expired / Lapsed
US
⏱️ 0.0 years remaining
APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same
Assignee: Bristol Myers Co
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Filing: 1975-10-08
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Granted: 1978-06-27
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Expires: 1995-10-08
Abstract
Abstract APAP tablet containing from about 190 to 1000 milligrams of APAP, from 25 to 100 milligrams of an alkali metal salt of a low substituted carboxymethyl starch such as sodium or potassium, and preferably sodium and, optionally, a non-toxic pharmaceutically acceptable binder in a quantity equal to or less than the amount of APAP in the tablet. Several methods are described for preparing these tablets.
Inventors
- 👤 Leonard Chavkin
- 👤 F. Henry Merkle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2059
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
110 words
As an article of manufacture, a tablet having a relatively high absorption rate for N-acetyl-p-aminophenol as measured by the blood plasma level of N-acetyl-p-aminophenol over time after ingestion comprising: (a) from about 190 to 1000 milligrams of N-acetyl-p-aminophenol; (b) from about 30 to 90 milligrams of a low substituted alkali metal carboxymethyl starch; and (c) a non-toxic, pharmaceutically acceptable binder; the ratio of N-acetyl-p-aminophenol to sodium alkali metal carboxymethyl starch, on a weight basis, being in the range of from about 5:1 to 10:1; the quantity of binder present being in the range of from 0 to an amount no greater than the amount of N-acetyl-p-aminophenol contained in the tablet.
Claim 2
Dependent Claim
110 words
As an article of manufacture, a tablet having a relatively high absorption rate for N-acetyl-p-aminophenol as measured by the blood plasma level of N-acetyl-p-aminophenol over time after ingestion comprising: (a) from about 190 to 1000 milligrams of N-acetyl-p-aminophenol; (b) from about 30 to 90 milligrams of a low substituted alkali metal carboxymethyl starch; and (c) a non-toxic, pharmaceutically acceptable binder; the ratio of N-acetyl-p-aminophenol to sodium alkali metal carboxymethyl starch, on a weight basis, being in the range of from about 5:1 to 10:1; the quantity of binder present being in the range of from 0 to an amount no greater than the amount of N-acetyl-p-aminophenol contained in the tablet.
Claim 3
Dependent Claim
10 words
A tablet according to claim 1 also including a lubricant.
Claim 4
Dependent Claim
16 words
A tablet according to claim 1 also containing up to 4 milligrams of a flow aid.
Claim 5
Dependent Claim
16 words
A tablet according to claim 2 also including up to 4 milligrams of a flow aid.
Claim 6
Dependent Claim
29 words
A tablet according to claim 1 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 7
Dependent Claim
29 words
A tablet according to claim 2 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 8
Dependent Claim
29 words
A tablet according to claim 3 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 9
Dependent Claim
29 words
A tablet according to claim 4 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 10
Dependent Claim
25 words
A tablet according to claim 1 in which the binder is present in an amount in the range of from about 150 to 500 milligrams.
Claim 11
Dependent Claim
14 words
A tablet according to claim 9 in which the binder is a microcrystalline cellulose.
Claim 12
Dependent Claim
10 words
A tablet according to claim 10 also including a lubricant.
Claim 13
Dependent Claim
17 words
A tablet according to claim 10 also including up to about 4 milligrams of a flow aid.
Claim 14
Dependent Claim
17 words
A tablet according to claim 11 also including up to about 4 milligrams of a flow aid.
Claim 15
Dependent Claim
29 words
A tablet according to claim 9 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 16
Dependent Claim
29 words
A tablet according to claim 10 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 17
Dependent Claim
29 words
A tablet according to claim 11 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 18
Dependent Claim
29 words
A tablet according to claim 12 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 19
Dependent Claim
29 words
A tablet according to claim 13 also including a material selected from the class consisting of disintegrants, diluents, sodium lauryl sulfate, calcium carbonate, polyvinylpyrrolidone, polyethylene glycol and mixtures thereof.
Claim 20
Dependent Claim
84 words
As an article of manufacture, a tablet having a relatively high absorption rate for N-acetyl-p-aminophenol as measured by the blood plasma level of N-acetyl-p-aminophenol over time after ingestion consisting essentially of: (a) from about 325 to 500 milligrams of N-acetyl-p-aminophenol; (b) from about 30 to 90 milligrams of a low substituted sodium carboxymethyl starch; and (c) from about 150 to 500 milligrams of microcrystalline cellulose; the ratio of N-acetyl-p-aminophenol to said sodium carboxymethyl starch being in the range of from about 5:1 to 10:1.
Claim 21
Dependent Claim
84 words
As an article of manufacture, a tablet having a relatively high absorption rate for N-acetyl-p-aminophenol as measured by the blood plasma level of N-acetyl-p-aminophenol over time after ingestion consisting essentially of: (a) from about 325 to 500 milligrams of N-acetyl-p-aminophenol; (b) from about 30 to 90 milligrams of a low substituted sodium carboxymethyl starch; and (c) from about 150 to 500 milligrams of microcrystalline cellulose; the ratio of N-acetyl-p-aminophenol to said sodium carboxymethyl starch being in the range of from about 5:1 to 10:1.
Claim 22
Dependent Claim
12 words
A tablet according to claim 19 including stearic acid as a lubricant.
Claim 23
Dependent Claim
19 words
A tablet according to claim 19 including up to 4 milligrams of colloidal silicon dioxide as a flow aid.
Claim 24
Dependent Claim
18 words
A tablet according to claim 21 in which the tablet contains about 0.5 milligrams of colloidal silicon dioxide.
Claim 25
Dependent Claim
11 words
A tablet according to claim 21 also including sodium lauryl sulfate.
Claim 26
Dependent Claim
10 words
A tablet according to claim 20 also including calcium carbonate.
Claim 27
Dependent Claim
57 words
A tablet according to claim 10 in which the degree of substitution of said low substituted alkali metal carboxymethyl starch is in the range of from 25 to 29 alkali metal carboxymethyl groups per 100 glucose units of said starch and said microcrystalline cellulose has a degree of polymerization in the range of from 210 to 230.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-26 | 1981-12-26 | 1982-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-26 | 1985-12-26 | 1986-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-26 | 1989-12-26 | 1990-06-27 | $7700.00 | Window Closed / Lapsed |