Apap tablet containing fumed silica and process for manufacturing same

Claim 1

A process for preparing a tablet containing n-acetyl-p-aminophenol in therapeutically effective quantities which comprises: a. forming a solution of n-acetyl-p-aminophenol in an organic solvent containing from about 1 to 30% by weight of n-acetyl-p-aminophenol based on the total weight of said solution; b. distributing in said solution from about 5.2% to 25% by weight based on the weight of n-acetyl-p-aminophenol of powdered fumed silicon dioxide to form a dispersion or suspension of said powdered fumed silicon dioxide is said solution; c. drying said dispersion or suspension to form a dried mix comprising n-acetyl-p-aminophenol and fumed silicon dioxide; and d. pressing a quantity of tabletting mix containing said dried particulate mix comprising a unit dosage amount of n-acetyl-p-aminophenol and fumed silicon dioxide to form a tablet; said organic solvent being selected so that said n-acetyl-p-aminophenol is soluble therein and said fumed silicon dioxide is substantially insoluble therein; the relative amounts of said n-acetyl-p-aminophenol and said fumed silicon dioxide employed being such that said dried mix contains from about 5 to 20% by weight of said fumed silicon dioxide based on the combined weight of n-acetyl-p-aminophenol and fumed silicon dioxide.