US3923969A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Carrier system for a drug with sustained release
Assignee: Battelle-Institut
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Filing: 1973-06-12
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Granted: 1975-12-02
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Expires: 1993-06-12
Abstract
Abstract A carrier system for a drug which allows the sustained and prolonged release of the drug which is comprised of (i) a porous carrier material which is insoluble or only slightly soluble in the body, which is in compacted form or powder form and which contains cavities which are connected to the outer surface by narrow pore necks, the mean diameters of the cavities in section being over twice as large as the mean internal widths of the necks of the pores, and the internal width of the necks of the pores being preponderantly less than 0.1 Mu m, and (ii) a drug or pharmaceutically active substance is embedded or contained in the cavities.
Inventors
- 👤 Werner Baukal
- 👤 Heinz-Joachim Kinkel
- 👤 Erich Robens
- 👤 Gerhard Walter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 11:14
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2009
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
178 words
A CARRIER SYSTEM FOR A DRUG WHICH ALLOWS THE SUTAINED AND PROPLONGED RELEASE OF THE DRUG WHICH CONSISTS OF I. A POROUS CARRIER ALUMINUM OXIDE MATERIAL WHICH IS INSOLUBLE OR ONLY SLIGHTLY SOLUBLE IN THE BODY WHICH IS IN DIRED JELLY LUMP FORM WHICH DISINTEGRATES INTO SMALL PARTICLES AND WHICH CONTAINS INKWELL PORE CAVITIES WHICH ARE CONNECTED TO THE OUTER SURFACE BY NARROW PORE NECKS, THE MEANS DIAMETERS OF THE INKWELL PORE CAVITIES IN SECTION BEING OVER TWICE AS LARGE AS THE MEANS INTERNAL WIDTHS OF THE NECKS OF THE INKWELL PORES, AND THE INTERNAL WIDTH OF THE NECKS OF THE INKWELL PORES BEING PREPONDERANTLY LESS THAN 0.1 UM AND II. A DRUG OR PHARMACETICALLY ACTIVE SUBSTANCE WHICH IS EMBEDDED OR CONTAINED ONLY IN SAID INKWELL PORE CAVITIES, AND WHICH JELLY HAS BEEN FORMED BY STIRRING TOGETHER DROPWISE A MIXTURE OF ALUMINUM ISOPROPONATE DISSOLVED IN VENZENE AND A MIXTURE OF WATER AND ISOPROPANOL, BOTH MIXTURES CONTAINING THE DRUG ALMOST TO THE POINT OF SATURATION, AND DRYING THE JELLY WHICH FORMED, TO A LUMP WHICH DISINTEGRATES INTO SMALL PARTICLES.
Claim 2
Dependent Claim
178 words
A CARRIER SYSTEM FOR A DRUG WHICH ALLOWS THE SUTAINED AND PROPLONGED RELEASE OF THE DRUG WHICH CONSISTS OF I. A POROUS CARRIER ALUMINUM OXIDE MATERIAL WHICH IS INSOLUBLE OR ONLY SLIGHTLY SOLUBLE IN THE BODY WHICH IS IN DIRED JELLY LUMP FORM WHICH DISINTEGRATES INTO SMALL PARTICLES AND WHICH CONTAINS INKWELL PORE CAVITIES WHICH ARE CONNECTED TO THE OUTER SURFACE BY NARROW PORE NECKS, THE MEANS DIAMETERS OF THE INKWELL PORE CAVITIES IN SECTION BEING OVER TWICE AS LARGE AS THE MEANS INTERNAL WIDTHS OF THE NECKS OF THE INKWELL PORES, AND THE INTERNAL WIDTH OF THE NECKS OF THE INKWELL PORES BEING PREPONDERANTLY LESS THAN 0.1 UM AND II. A DRUG OR PHARMACETICALLY ACTIVE SUBSTANCE WHICH IS EMBEDDED OR CONTAINED ONLY IN SAID INKWELL PORE CAVITIES, AND WHICH JELLY HAS BEEN FORMED BY STIRRING TOGETHER DROPWISE A MIXTURE OF ALUMINUM ISOPROPONATE DISSOLVED IN VENZENE AND A MIXTURE OF WATER AND ISOPROPANOL, BOTH MIXTURES CONTAINING THE DRUG ALMOST TO THE POINT OF SATURATION, AND DRYING THE JELLY WHICH FORMED, TO A LUMP WHICH DISINTEGRATES INTO SMALL PARTICLES.
References Cited (Backward Citations)
US2038694A
Cited
US3148124A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-01 | 1979-06-02 | 1979-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-01 | 1983-06-02 | 1983-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-01 | 1987-06-02 | 1987-12-02 | $7700.00 | Window Closed / Lapsed |