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US4096252A
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4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents
Assignee: Noucor Health SA
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Filing: 1976-06-10
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Granted: 1978-06-20
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Expires: 1996-06-10
Abstract
Abstract 2-OR-4-trifluoromethylbenzoic acid wherein R is H or acyl. The compounds are useful in the treatment of pathological cardiovascular conditions, particularly in the prophylaxis of the thromboembolic diseases. The compounds are made by reacting m-trifluoromethyl phenol with potassium carbonate and carbon dioxide at an elevated temperature and pressure and, if desired, acetylating the 2-OH compound thus obtained or reacting it with a phosphonating agent. The invention also embraces pharmaceutical compositions in which the compounds constitute the effective agent and a method of treatment.
Inventors
- 👤 Emilia Francia Barra
- 👤 Antonio Carmelo Marin Moga
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 07:19
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/12; A; A61; A61P; A61P7/00; A61P7/02; C07C; C07C51/00; C07C51/15
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
91 words
A method for the treatment and prophylaxis of cardiovascular conditions due to an abnormal platelet aggregation, coagulation and fibrinolysis comprising administering to a patient by oral administration a compound of the formula ##STR6## wherein R is hydrogen or lower alkanoyl as active agent, together with a carrier therefor, at a dosage of about 1 to 6 unit doses of about 200 to 300 mg each of said active agent or about 1 to 6 units at about 5 ml each of the active agent when in the form of a syrup.
Claim 2
Independent Claim
91 words
A method for the treatment and prophylaxis of cardiovascular conditions due to an abnormal platelet aggregation, coagulation and fibrinolysis comprising administering to a patient by oral administration a compound of the formula ##STR6## wherein R is hydrogen or lower alkanoyl as active agent, together with a carrier therefor, at a dosage of about 1 to 6 unit doses of about 200 to 300 mg each of said active agent or about 1 to 6 units at about 5 ml each of the active agent when in the form of a syrup.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the said active agent is 2-acetoxy-4-trifluoromethylbenzoic acid.
References Cited (Backward Citations)
US3019253A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-19 | 1981-12-19 | 1982-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-19 | 1985-12-19 | 1986-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-19 | 1989-12-19 | 1990-06-20 | $7700.00 | Window Closed / Lapsed |