US4094744A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Water-dispersible protein/polyurethane reaction product
Assignee: WR Grace and Co
•
Filing: 1976-12-10
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Granted: 1978-06-13
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Expires: 1996-12-10
Abstract
Abstract An aqueous dispersion of a biologically-active protein bound to polyurethane is formed by (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer to form a solution; and (b) dispersing the solution in water.
Inventors
- 👤 Frank Joseph Hartdegen
- 👤 Wayne Elliott Swann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:24
CPC Classifications
C; C08; C08G; C08G18/00; C08G18/06; C08G18/08; C08G18/10; C08G18/28; C08G18/40; C08G18/64; C08G18/6415; C08G18/6446; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/089; C12N11/093; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
85 words
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising: a. admixing a water-dispersible, biologically-active protein and an isocyanate-capped liquid polyurethane prepolymer having an oxyalkylene backbone containing at least 50 mole % of oxyethylene units under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together; and b. dispersing the solution in water with agitation to form an aqueous solution of urethane-polymer bound protein.
Claim 2
Independent Claim
85 words
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising: a. admixing a water-dispersible, biologically-active protein and an isocyanate-capped liquid polyurethane prepolymer having an oxyalkylene backbone containing at least 50 mole % of oxyethylene units under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together; and b. dispersing the solution in water with agitation to form an aqueous solution of urethane-polymer bound protein.
Claim 3
Dependent Claim
18 words
A method as in claim 1 wherein the aqueous solution of protein bound to urethane polymer is filtered.
Claim 4
Dependent Claim
12 words
A method as in claim 1 wherein the protein is an enzyme.
Claim 5
Dependent Claim
44 words
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane characterized as having an essentially linear polyoxyalkylene backbone containing at least 50 mole % of oxyethylene units, said protein bound to said polyurethane through a ureido linkage, said polyurethane-bound protein being water-soluble.
Claim 6
Dependent Claim
44 words
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane characterized as having an essentially linear polyoxyalkylene backbone containing at least 50 mole % of oxyethylene units, said protein bound to said polyurethane through a ureido linkage, said polyurethane-bound protein being water-soluble.
Claim 7
Dependent Claim
13 words
An aqueous solution as in claim 4 wherein the protein is an enzyme.
Claim 8
Dependent Claim
85 words
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane, said bound protein formed by dissolving the protein in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together; said prepolymer having an essentially linear oxyalkylene backbone containing at least 50 mole % oxyethylene units; and dispersing the solution in water with agitation to form a solution of polyurethane bound protein.
Claim 9
Dependent Claim
85 words
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane, said bound protein formed by dissolving the protein in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together; said prepolymer having an essentially linear oxyalkylene backbone containing at least 50 mole % oxyethylene units; and dispersing the solution in water with agitation to form a solution of polyurethane bound protein.
Claim 10
Dependent Claim
13 words
An aqueous solution as in claim 6 wherein the protein is an enzyme.
Claim 11
Dependent Claim
35 words
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane characterized as having an essentially linear polyester backbone, said protein bound to said polyurethane through a ureido linkage, said polyurethane-bound protein being water-soluble.
Claim 12
Dependent Claim
35 words
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane characterized as having an essentially linear polyester backbone, said protein bound to said polyurethane through a ureido linkage, said polyurethane-bound protein being water-soluble.
Claim 13
Dependent Claim
13 words
An aqueous solution as in claim 8 wherein the protein is an enzyme.
Claim 14
Independent Claim
77 words
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising: a. admixing a water-dispersible, biologically-active protein and an isocyanate-capped liquid polyurethane prepolymer having a linear polyester backbone under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together; and b. dispersing the solution in water with agitation to form an aqueous solution of urethane-polymer bound protein.
Claim 15
Independent Claim
77 words
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising: a. admixing a water-dispersible, biologically-active protein and an isocyanate-capped liquid polyurethane prepolymer having a linear polyester backbone under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together; and b. dispersing the solution in water with agitation to form an aqueous solution of urethane-polymer bound protein.
Claim 16
Dependent Claim
19 words
A method as in claim 10 including a step of filtering the aqueous solution to remove nondispersible protein/polyurethane compounds.
Claim 17
Dependent Claim
12 words
A method as in claim 10 wherein the protein is an enzyme.
Claim 18
Independent Claim
65 words
A method for preparing an aqueous dispersion of enzyme bound to a urethane polymer comprising: a. dispersing an enzyme in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution; b. forming a dispersion by slowly adding said enzyme/polyurethane composition to water while agitating, and continuing agitation following addition of said composition; and c. separating insoluble bound enzymes from the aqueous dispersion.
Claim 19
Independent Claim
65 words
A method for preparing an aqueous dispersion of enzyme bound to a urethane polymer comprising: a. dispersing an enzyme in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution; b. forming a dispersion by slowly adding said enzyme/polyurethane composition to water while agitating, and continuing agitation following addition of said composition; and c. separating insoluble bound enzymes from the aqueous dispersion.
Claim 20
Independent Claim
51 words
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising: a. dispersing of biologically-active protein in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution; and b. dispersing the solution in water with agitation to form a solution of urethane polymer-bound protein.
Claim 21
Independent Claim
51 words
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising: a. dispersing of biologically-active protein in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution; and b. dispersing the solution in water with agitation to form a solution of urethane polymer-bound protein.
Claim 22
Dependent Claim
13 words
A method as in claim 14 wherein the polyurethane has a polyoxyalkylene backbone.
Claim 23
Dependent Claim
18 words
A method as in claim 15 wherein the backbone contains at least 50 mole % of oxyethylene units.
Claim 24
Dependent Claim
13 words
A method as in claim 14 wherein the polyurethane has a polyester backbone.
Claim 25
Dependent Claim
17 words
A method as in claim 14 wherein the solution is dispersed with the aid of a surfactant.
Claim 26
Dependent Claim
35 words
A method as in claim 14 wherein the prepolymer is dissolved in a water-immiscible organic solvent and the protein is dissolved in said prepolymer/solvent solution to form the solution of part a of claim 14.
References Cited (Backward Citations)
US3672955A
Cited
US3928138A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-12 | 1981-12-12 | 1982-06-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-12 | 1985-12-12 | 1986-06-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-12 | 1989-12-12 | 1990-06-13 | $7700.00 | Window Closed / Lapsed |