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US4093796A
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Antibiotic derivatives of polyene macrolide group and method of obtaining the same
Assignee: Gdańsk University of Technology
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Filing: 1972-08-10
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Granted: 1978-06-06
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Expires: 1992-08-10
Abstract
Abstract A new class of polyene macrolide antibiotics which exhibit valuable therapeutic properties are obtained by reaction of said antibiotics containing at least one amino group with mono- or oligosaccharides, and/or their derivatives in a suitable solvent.
Inventors
- 👤 Leonard Falkowski
- 👤 Miroslaw Bobrowski
- 👤 Helena Buluk
- 👤 Elzbieta Bylec
- 👤 Barbara Cybulska
- 👤 Jerzy Golik
- 👤 Pawel Kolodziejczyk
- 👤 Jan Pawlak
- 👤 Andrzej Rudowski
- 👤 Jan Zielinski
- 👤 Tadeusz Ziminski
- 👤 Edward Borowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 23:29
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
34 words
The N-glycosyl reaction product of an amino group-containing polyene macrolide antibiotic obtained by reacting said antibiotic with a saccharide selected from the group consisting of aldose monosaccharides, ketose monosaccharides, aldose oligosaccharides and oligosaccharides. oligosacharides.
Claim 2
Dependent Claim
34 words
The N-glycosyl reaction product of an amino group-containing polyene macrolide antibiotic obtained by reacting said antibiotic with a saccharide selected from the group consisting of aldose monosaccharides, ketose monosaccharides, aldose oligosaccharides and oligosaccharides. oligosacharides.
Claim 3
Dependent Claim
31 words
The product according to claim 1 wherein the polyene macrolide antibiotic is selected from the group consisting of pimaricin, rimocidin, nystatin, polyfungin, amphotericin B, candidin, mycoheptin, candicidin, trichomycin, levorin and aurofacin.
Claim 4
Dependent Claim
26 words
The product according to claim 2 wherein the saccharide is selected from the group consisting of glucose, matlose, ribose, fructose, rhamnose, glucuronic acid, acetylglucose and bromoacetylglucose.
Claim 5
Dependent Claim
10 words
The product according to claim 3 which is glucosyl pimaricin.
Claim 6
Dependent Claim
10 words
The product according to claim 3 which is glucosyl mystatin.
Claim 7
Dependent Claim
10 words
The product according to claim 3 which is glucosyl polyfungin.
Claim 8
Dependent Claim
11 words
The product according to claim 3 which is glucosyl amphotericin B.
Claim 9
Dependent Claim
10 words
The product according to claim 3 which is glucosyl mycoheptin.
Claim 10
Dependent Claim
10 words
The product according to claim 3 which is glucosyl candicidin.
Claim 11
Dependent Claim
10 words
The product according to claim 3 which is glucosyl trichomycin.
Claim 12
Dependent Claim
10 words
The product according to claim 3 which is glucosyl levorin.
Claim 13
Dependent Claim
10 words
The product according to claim 3 which is glucosyl aureofacin.
Claim 14
Dependent Claim
10 words
The product according to claim 3 which is glucosyl perimycin.
Claim 15
Dependent Claim
11 words
The product according to claim 3 wherein the antibiotic is nystatin.
Claim 16
Dependent Claim
26 words
A method of preparing the reaction product according to claim 1 comprising reacting said antibiotic with said saccharide in a solvent and isolating the reaction product.
Claim 17
Dependent Claim
24 words
A method according to claim 15 wherein the solvent is selected from the group consisting of dimethylformamide, methanol, dimethylsulfoxide and pyridine and mixtures thereof.
Claim 18
Dependent Claim
26 words
A method according to claim 15 wherein the reaction is carried out in the presence of a base which forms a salt with the reaction product.
Claim 19
Dependent Claim
24 words
A method according to claim 15 which further comprises reacting the reaction product with a base which forms a salt with said reaction product.
Claim 20
Dependent Claim
25 words
A method according to claim 18 wherein the salt-forming base is selected from the group consisting of sodium carbonate, sodium hydroxide, imidazole and 2-amino-2(hydroxymethyl) propane-1,3-diol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-05 | 1981-12-05 | 1982-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-05 | 1985-12-05 | 1986-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-05 | 1989-12-05 | 1990-06-06 | $7700.00 | Window Closed / Lapsed |