Patent US4093629A successfully refreshed from Google Patents.
US4093629A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of antibiotic substance milbemycin and processes therefor
Assignee: Merck and Co Inc
•
Filing: 1977-04-11
•
Granted: 1978-06-06
•
Expires: 1997-04-11
Abstract
Abstract Derivatives of the antibiotic substance milbemycin, also identified as B-41 are prepared. Milbemycin is brominated, acetylated and hydrolized in order to prepare the 13-hydroxy derivative thereof. The novel derivatives have antiparasitic activity.
Inventors
- 👤 Michael H. Fisher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:37
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/01; A; A61; A61P; A61P33/00; A61P33/10
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
29 words
13-Hydroxy milbemycin A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 .
Claim 2
Dependent Claim
29 words
13-Hydroxy milbemycin A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 .
Claim 3
Dependent Claim
29 words
13-Bromo milbemycin A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 .
Claim 4
Dependent Claim
29 words
13-Bromo milbemycin A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 .
Claim 5
Dependent Claim
29 words
13-Acetoxy milbemycin A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 .
Claim 6
Dependent Claim
29 words
13-Acetoxy milbemycin A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 .
Claim 7
Dependent Claim
63 words
A process for the preparation of 13-hydroxy milbemycins A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 which comprises: (a) brominating the 13-unsubstituted milbemycins with N-bromosuccinimide; (b) acetylating the 13-bromomilbemycins with an alkali metal acetate; and (c) hydrolizing the 13-acetoxy milbemycins with aqueous alkali metal hydroxide.
Claim 8
Dependent Claim
63 words
A process for the preparation of 13-hydroxy milbemycins A 1 , A 2 , A 3 , A 4 , B 1 , B 2 , B 3 , C 1 or C 2 which comprises: (a) brominating the 13-unsubstituted milbemycins with N-bromosuccinimide; (b) acetylating the 13-bromomilbemycins with an alkali metal acetate; and (c) hydrolizing the 13-acetoxy milbemycins with aqueous alkali metal hydroxide.
References Cited (Backward Citations)
US3950360A
Cited
US3984564A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-05 | 1981-12-05 | 1982-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-05 | 1985-12-05 | 1986-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-05 | 1989-12-05 | 1990-06-06 | $7700.00 | Window Closed / Lapsed |