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US4092321A
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US
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Process for the preparation of imidazo [1,2-a] pyridines
Assignee: Merck and Co Inc
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Filing: 1977-06-16
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Granted: 1978-05-30
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Expires: 1997-06-16
Abstract
Abstract Processes are described for the preparation of 2-(methoxycarbonylamino)-6-(phenylsulfinyl) imidazo [1,2-a] pyridine, which is an active anthelmintic agent. The process involves the treatment of a 5-phenylsulfinyl pyridine substituted at the 2-position with a leaving group, with methylchloroacetylcarbamate followed by treatment with ammonia.
Inventors
- 👤 Richard J. Bochis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:15
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/70; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
51 words
A process for the preparation of a compound having the formula: ##STR6## which comprises treating a compound having the formula: ##STR7## wherein X is a halogen, loweralkoxy or loweralkylthio, with methyl chloroacetyl carbamate to form: ##STR8## which is treated with ammonia and then heated in order to form the desired product.
Claim 2
Dependent Claim
51 words
A process for the preparation of a compound having the formula: ##STR6## which comprises treating a compound having the formula: ##STR7## wherein X is a halogen, loweralkoxy or loweralkylthio, with methyl chloroacetyl carbamate to form: ##STR8## which is treated with ammonia and then heated in order to form the desired product.
Claim 3
Dependent Claim
13 words
The process of claim 1 wherein X is chlorine, bromine, methoxy or methylthio.
Claim 4
Dependent Claim
17 words
The process of claim 2 wherein the heating step is carried out in the presence of methanol.
Claim 5
Dependent Claim
54 words
A process for the preparation of a compound having the formula: ##STR9## which comprises treating a compound having the formula: ##STR10## wherein X is a halogen, loweralkoxy or loweralkylthio, with methylchloroacetylcarbamate to form: ##STR11## which is treated with ammonia and then heated in order to form: ##STR12## which is oxidized to the desired product.
Claim 6
Dependent Claim
54 words
A process for the preparation of a compound having the formula: ##STR9## which comprises treating a compound having the formula: ##STR10## wherein X is a halogen, loweralkoxy or loweralkylthio, with methylchloroacetylcarbamate to form: ##STR11## which is treated with ammonia and then heated in order to form: ##STR12## which is oxidized to the desired product.
Claim 7
Dependent Claim
13 words
The process of claim 4 wherein X is chlorine, bromine, methoxy or methylthio.
Claim 8
Dependent Claim
17 words
The process of claim 5 wherein the heating step is carried out in the presence of methanol.
References Cited (Backward Citations)
US3701780A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-29 | 1981-11-28 | 1982-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-29 | 1985-11-28 | 1986-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-29 | 1989-11-28 | 1990-05-30 | $7700.00 | Window Closed / Lapsed |