US4087545A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
Assignee: Eli Lilly and Co
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Filing: 1976-02-17
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Granted: 1978-05-02
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Expires: 1996-02-17
Abstract
Abstract Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as antiemetic drugs.
Inventors
- 👤 Robert A. Archer
- 👤 Louis Lemberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:25
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/02; C07D493/10; C07D311/00; C07D311/02; C07D311/04; C07D311/06; C07D311/08; C07D311/16; C07D311/78; C07D311/80
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
90 words
A process for providing prevention and treatment of emesis and nausea in mammals which comprises administering to a nauseated mammal an anti-emetic dose of a compound represented by the formula ##STR9## wherein R' is either C 7 -C 10 normal alkyl or is the group ##STR10## wherein R" is C 2 -C 7 alkyl and R v is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C 1 -C 4 alkanoyl, in an amount effective to prevent nausea.
Claim 2
Dependent Claim
90 words
A process for providing prevention and treatment of emesis and nausea in mammals which comprises administering to a nauseated mammal an anti-emetic dose of a compound represented by the formula ##STR9## wherein R' is either C 7 -C 10 normal alkyl or is the group ##STR10## wherein R" is C 2 -C 7 alkyl and R v is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C 1 -C 4 alkanoyl, in an amount effective to prevent nausea.
Claim 3
Dependent Claim
23 words
A process according to claim 1 in which a dose of from 0.1 to 100 mgs per day of the drug is administered.
Claim 4
Dependent Claim
23 words
A process according to claim 1 in which a dose of from 1 to 20 mgs. per day of the drug is administered.
Claim 5
Dependent Claim
16 words
A process according to claim 1 in which the drug is administered by the oral route.
Claim 6
Dependent Claim
11 words
A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.
Claim 7
Dependent Claim
11 words
A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',2'-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.
Claim 8
Dependent Claim
11 words
A process according to claim 1 in which dl-trans-1-hydroxy-3-(1'-methylheptyl)-6,6a,7,8,10,10a-hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-01 | 1981-10-31 | 1982-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-01 | 1985-10-31 | 1986-05-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-01 | 1989-10-31 | 1990-05-02 | $7700.00 | Window Closed / Lapsed |