Patent US4086266A successfully refreshed from Google Patents.
US4086266A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of bacterially purifying methyl cyanoacrylate
Assignee: TRI-POINT MEDICAL Corp
•
Filing: 1977-04-06
•
Granted: 1978-04-25
•
Expires: 1997-04-06
Abstract
Abstract A process is described whereby methyl cyanoacrylate (MCA) may be bacterially made sterile without the degradation of the product by partial or total polymerization and without the introduction of or creation of materials which are adverse to the use of the MCA in vivo in the human body. The process utilizes a filtration technique including a polytetrafluoroethylene (Teflon) filter element.
Inventors
- 👤 Harold Corey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 05:45
CPC Classifications
C; C07; C07C; C07C255/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
93 words
The method of providing a bacterially sterile monomer of an aliphatic cyanoacrylate comprising: (a) preparing a substantially monomeric aliphatic cyanoacrylate that is greater than 99% pure monomer; (b) providing a sterilized Teflon filter element having a pore size of about 0.20 micrometer; (c) treating said Teflon filter element by vacuum heating to a temperature of about 100° C to desorb water and substantially all other volatile polymerization catalyst materials from the surface of the filter element; and, (d) filtering said monomeric aliphatic cyanoacrylate through said Teflon filter element to remove all bacteria therefrom.
Claim 2
Independent Claim
93 words
The method of providing a bacterially sterile monomer of an aliphatic cyanoacrylate comprising: (a) preparing a substantially monomeric aliphatic cyanoacrylate that is greater than 99% pure monomer; (b) providing a sterilized Teflon filter element having a pore size of about 0.20 micrometer; (c) treating said Teflon filter element by vacuum heating to a temperature of about 100° C to desorb water and substantially all other volatile polymerization catalyst materials from the surface of the filter element; and, (d) filtering said monomeric aliphatic cyanoacrylate through said Teflon filter element to remove all bacteria therefrom.
Claim 3
Dependent Claim
28 words
The method in accordance with claim 1 wherein the filter element is flushed with ethylene oxide gas subsequent to vacuum heating and revacuumed to remove the ethylene oxide.
Claim 4
Dependent Claim
34 words
The method in accordance with claim 1 wherein a small quantity, below about 100 ppm, of a Lewis acid polymerization inhibitor is added to said aliphatic cyanoacrylate prior to passage through said filter element.
Claim 5
Dependent Claim
25 words
The method in accordance with claim 3 wherein said polymerization inhibitor is selected from the group consisting of sulfur dioxide, isethionic acid and phosphoric acid.
Claim 6
Dependent Claim
41 words
The method in accordance with claim 1 wherein a small quantity, below about 100 ppm, of the polymerization inhibitor selected from the group hydroquinone and butylated hydroxy toluene is added to the aliphatic cyanoacrylate prior to passing through said filter element.
Claim 7
Dependent Claim
15 words
The method in accordance with claim 1 wherein said aliphatic cyanoacrylate monomer is methyl cyanoacrylate.
Claim 8
Dependent Claim
33 words
The method in accordance with claim 6 wherein a small quantity, below about 100 ppm, of a Lewis acid is added to said methyl cyanoacrylate prior to filtering it through said filter element.
Claim 9
Dependent Claim
14 words
The method in accordance with claim 6 wherein the Lewis acid is isethionic acid.
Claim 10
Dependent Claim
19 words
The method in accordance with claim 1 in which the filtering step is accomplished with the aid of pressure.
References Cited (Backward Citations)
US2763677A
Cited
US3250002A
Cited
GB1159548A
Cited
US3759264A
Cited
US3360124A
Cited
US3699076A
Cited
US3527841A
Cited
US3564078A
Cited
US3948259A
Cited
US3822702A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-24 | 1981-10-24 | 1982-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-24 | 1985-10-24 | 1986-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-24 | 1989-10-24 | 1990-04-25 | $7700.00 | Window Closed / Lapsed |